Phenotypes associated with this allele

• Allele Symbol: Tmem127^{tm1(KOMP)Wtsi}
• Allele Name: targeted mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:4419725
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem127^tm1(KOMP)Wtsi/Tmem127^tm1(KOMP)Wtsi	C57BL/6N-Tmem127^tm1(KOMP)Wtsi/Wtsi	MGI:5701019

Genotype
MGI:5701019

hm1

• Allelic Composition: Tmem127^{tm1(KOMP)Wtsi}/Tmem127^{tm1(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Tmem127^{tm1(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0406_4_C10

Data Sources

IMPC Data for Tmem127

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:211773 )

♂

IMPC - WTSI

hematopoietic system

decreased neutrophil cell number ( J:211773 )

IMPC - WTSI

thrombocytopenia ( J:211773 )

IMPC - WTSI

decreased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

decreased B cell number ( J:211773 )

IMPC - WTSI

decreased B-2 B cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

♂

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased T cell number ( J:211773 )

IMPC - WTSI

increased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - WTSI

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

IMPC - WTSI

decreased monocyte cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C high monocyte number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

♀

IMPC - WTSI

increased circulating bilirubin level ( J:211773 )

♀

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - WTSI

increased circulating amylase level ( J:211773 )

IMPC - WTSI

immune system

decreased neutrophil cell number ( J:211773 )

IMPC - WTSI

decreased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

decreased B cell number ( J:211773 )

IMPC - WTSI

decreased B-2 B cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

♂

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased T cell number ( J:211773 )

IMPC - WTSI

increased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - WTSI

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

IMPC - WTSI

decreased monocyte cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C high monocyte number ( J:211773 )

IMPC - WTSI

integument

abnormal nail morphology ( J:211773 )

♀

IMPC - WTSI

skeleton

increased bone mineral content ( J:211773 )

♀

IMPC - WTSI