Phenotypes associated with this allele

• Allele Symbol: Bola2^{tm1(KOMP)Wtsi}
• Allele Name: targeted mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:4419429
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bola2^tm1(KOMP)Wtsi/Bola2^tm1(KOMP)Wtsi	C57BL/6N-Bola2^tm1(KOMP)Wtsi/Nju	MGI:5797405
ht2	Bola2^tm1(KOMP)Wtsi/Bola2^+	C57BL/6N-Bola2^tm1(KOMP)Wtsi	MGI:8209495

Genotype
MGI:5797405

hm1

• Allelic Composition: Bola2^{tm1(KOMP)Wtsi}/Bola2^{tm1(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Bola2^{tm1(KOMP)Wtsi}/Nju
• Cell Lines: EPD0384_6_A09

Data Sources

IMPC Data for Bola2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased hemoglobin content ( J:211773 )

♀

IMPC - MARC

decreased mean corpuscular volume ( J:211773 )

♀

IMPC - MARC

homeostasis/metabolism

decreased circulating iron level ( J:211773 )

IMPC - MARC

improved glucose tolerance ( J:211773 )

♀

IMPC - MARC

integument

abnormal coat/hair pigmentation ( J:211773 )

IMPC - MARC

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

IMPC - MARC

Genotype
MGI:8209495

ht2

• Allelic Composition: Bola2^{tm1(KOMP)Wtsi}/Bola2⁺
• Genetic Background: C57BL/6N-Bola2^{tm1(KOMP)Wtsi}

nervous system

decreased brain size ( J:343325 )

♀ • in adult females, total brain area is reduced by 9% relative to wild-type females

small third ventricle ( J:343325 )

♂ • in adult males, the area of the dorsal third ventricle is smaller by no less than 40% relative to wild-type males

decreased corpus callosum size ( J:343325 )

• in adult males, the area of the soma of the corpus callosum is decreased by 10% while the height of the same structure is reduced by 11% relative to wild-type males

• in adult females, the height of the genu of the corpus callosum is reduced by 15% while the soma of the corpus callosum is smaller by 14% for its area, 11% for its width and 10% for its height

small hippocampus ( J:343325 )

♂ • in adult males, the area of the hippocampus is smaller by 12% relative to wild-type males

decreased secondary somatosensory cortex size ( J:343325 )

♀ • in adult females, the height of the secondary somatosensory cortex is thinner by 11% relative to wild-type females