All Phenotypes Ntsr1<tm2Pang> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ntsr1^tm2Pang
targeted mutation 2, Zhen Pang
MGI:4418470

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntsr1^tm2Pang/Ntsr1^tm2Pang	involves: 129P2/OlaHsd * C57BL/6J	MGI:4418497

Allelic Composition	Ntsr1^tm2Pang/Ntsr1^tm2Pang
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntsr1^tm2Pang mutation (0 available); any Ntsr1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

• maintain a normal body temperature in response to NT-2 and NT69L (neurotensin agonists) unlike controls which become hypothermic

behavior/neurological

increased vertical activity ( J:155994 )

• neurotensin agonists fail to reduce spontaneous climbing behavior

• neurotensin agonists fail to reduce climbing in response to apomorphine

abnormal thermal nociception ( J:155994 )

• neurotensin agonists fail to increase the latency of response to thermal stimulus in a tail immersion test

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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