Phenotypes associated with this allele

• Allele Symbol: Asxl1^tm1Bc
• Allele Name: targeted mutation 1, University of British Columbia
• Allele ID: MGI:4418244
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Asxl1^tm1Bc/Asxl1^tm1Bc	involves: 129P2/OlaHsd * C57BL/6J	MGI:4418253

Genotype
MGI:4418253

hm1

• Allelic Composition: Asxl1^tm1Bc/Asxl1^tm1Bc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal thymus morphology ( J:155898 )

• thymus cellularity is drastically reduced in mice over 15 weeks of age

spleen hyperplasia ( J:155898 )

• some mice show increased splenic cellularity

abnormal blood cell morphology/development ( J:155898 )

abnormal common myeloid progenitor cell morphology ( J:155898 )

• slight reduction in colony formation of granulocyte-macrophage progenitors in embryonic and young mice

• slight reduction in colony formation of granulocyte-macrophage-megakaryocyte progenitors in embryonic and young mice

abnormal lymphopoiesis ( J:155898 )

increased double-negative T cell number ( J:155898 )

• relative

extramedullary hematopoiesis ( J:155898 )

• seen in some adult mice in the spleen red pulp

decreased bone marrow cell number ( J:155898 )

• modest reductions in bone marrow in mice under 15 weeks of age becoming significantly reduced after 15 weeks

decreased B cell number ( J:155898 )

• some mice over 15 weeks of age show a relative decrease in B-lymphocyte numbers

• modest reductions in bone marrow in mice under 15 weeks of age becoming significantly reduced after 15 weeks

decreased pre-B cell number ( J:155898 )

• severely reduced numbers

• pro-B cell numbers are normal

decreased T cell number ( J:155898 )

• absolute numbers of all CD4+ and CD8+ populations are reduced in the thymus

• absolute numbers of all CD4+ and CD8+ populations are normal in the peripheral circulation

decreased CD4-positive, alpha-beta T cell number ( J:155898 )

• modest proportional reduction in embryos

immune system

abnormal immune system cell morphology ( J:155898 )

abnormal lymphopoiesis ( J:155898 )

increased double-negative T cell number ( J:155898 )

• relative

decreased B cell number ( J:155898 )

• some mice over 15 weeks of age show a relative decrease in B-lymphocyte numbers

• modest reductions in bone marrow in mice under 15 weeks of age becoming significantly reduced after 15 weeks

decreased pre-B cell number ( J:155898 )

• severely reduced numbers

• pro-B cell numbers are normal

decreased T cell number ( J:155898 )

• absolute numbers of all CD4+ and CD8+ populations are reduced in the thymus

• absolute numbers of all CD4+ and CD8+ populations are normal in the peripheral circulation

decreased CD4-positive, alpha-beta T cell number ( J:155898 )

• modest proportional reduction in embryos

abnormal immune system organ morphology ( J:155898 )

abnormal thymus morphology ( J:155898 )

• thymus cellularity is drastically reduced in mice over 15 weeks of age

spleen hyperplasia ( J:155898 )

• some mice show increased splenic cellularity

endocrine/exocrine glands

abnormal thymus morphology ( J:155898 )

• thymus cellularity is drastically reduced in mice over 15 weeks of age

growth/size/body

spleen hyperplasia ( J:155898 )

• some mice show increased splenic cellularity