Phenotypes associated with this allele

• Allele Symbol: Tg(ACTA1-Il15*)11650Lsq
• Allele Name: transgene insertion 11650, LeBris Smith Quinn
• Allele ID: MGI:4417881
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(ACTA1-Il15*)11650Lsq/0	involves: C3H * C57BL/6	MGI:4417908

Genotype
MGI:4417908

tg1

• Allelic Composition: Tg(ACTA1-Il15*)11650Lsq/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased lean body mass ( J:145611 )

♀ • females show increased lean mass after low and high fat feeding compared to controls

♀ • however, on a moderate fat breeder diet no differences in lean body mass are detected

abnormal body weight ( J:145611 )

• on both low and high fat diets, males gain less weight than controls, whereas females gain significantly more weight compared to controls on both diets

decreased body weight ( J:145611 )

♂ • in males, overall body weight is significantly decreased

immune system

abnormal interleukin level ( J:145611 )

• Il-15 protein levels are higher in muscle relative to controls; females display higher levels than males

increased circulating interleukin-15 level ( J:145611 )

• protein levels are higher than in controls; females have higher levels than males

• circulating levels of other cytokines are not affected by genotype

homeostasis/metabolism

decreased circulating leptin level ( J:145611 )

♂ • males, but not females, have significantly lower fasting serum leptin levels compared to controls

abnormal interleukin level ( J:145611 )

• Il-15 protein levels are higher in muscle relative to controls; females display higher levels than males

increased circulating interleukin-15 level ( J:145611 )

• protein levels are higher than in controls; females have higher levels than males

• circulating levels of other cytokines are not affected by genotype

adipose tissue

decreased abdominal adipose tissue amount ( J:145611 )

decreased fat cell size ( J:145611 )

♂ • mean visceral fat cell cross-sectional area in males is about 50% of that of controls, but is not different in females

decreased percent body fat/body weight ( J:145611 )

• significantly reduced in males and females relative to controls

skeleton

increased bone mineral content ( J:145611 )

• bone mineral content is significantly higher relative to controls, with males show an 8% elevation and females a 24% elevation in bone mineral content

hematopoietic system

hematopoietic system phenotype ( J:145611 )

N • no splenic enlargement or increased cellularity of the spleen or blood is detected

muscle

decreased extensor digitorum longus weight ( J:145611 )

♂ • wet weight of fast-twitch muscle is significantly lower in males, but not in females

limbs/digits/tail

decreased extensor digitorum longus weight ( J:145611 )

♂ • wet weight of fast-twitch muscle is significantly lower in males, but not in females