Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata5tm1Eem mutation
(0 available);
any
Gata5 mutation
(17 available)
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reproductive system
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• the distance between the vagina and anus is decreased compared to in wild-type mice
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• female mice exhibit genitourinary abnormalities identical to Gata5tm1Eno homozygotes
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renal/urinary system
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• female mice exhibit genitourinary abnormalities identical to Gata5tm1Eno homozygotes
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digestive/alimentary system
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• the distance between the vagina and anus is decreased compared to in wild-type mice
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Allelic Composition |
Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Jml mutation
(0 available);
any
Gata4 mutation
(36 available)
Gata5tm1Eem mutation
(0 available);
any
Gata5 mutation
(17 available)
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Ventriclular abnormalities in Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5tm1Eem and Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5+ mice
cardiovascular system
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• at E14.5, myocardial compact zone thickness is reduced 32% compared to in wild-type mice
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• as early as E12.5, the thickness of the ventricular compact myocardial layer is reduced 43% compared to in wild-type mice
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• some mice exhibit abnormal conoventricular septal defects (incomplete penetrance)
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muscle
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• at E14.5, myocardial compact zone thickness is reduced 32% compared to in wild-type mice
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• as early as E12.5, the thickness of the ventricular compact myocardial layer is reduced 43% compared to in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Jml mutation
(0 available);
any
Gata4 mutation
(36 available)
Gata5tm1Eem mutation
(0 available);
any
Gata5 mutation
(17 available)
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Ventriclular abnormalities in Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5tm1Eem and Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5+ mice
mortality/aging
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• mice do not survive past E14.5 with no live mice found in newborn litters
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cardiovascular system
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• fine, abnormal trabecular structures
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• at E12.5, the thickness of the ventricular compact myocardial layer is reduced 61% compared to in wild-type mice
• at E14.5, the ventricular compact myocardial layer thickness is reduced 84% compared to in wild-type mice
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• conotruncal cushions are reduced in size and altered in location compared to in wild-type mice leading to abnormalities in ventriculoarterial positioning
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• endocardial cushions are hypoplastic at E12.5
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• mice exhibit a primum atrial septal defect unlike wild-type mice
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• mice exhibit a common atrioventricular canal and occasionally an unbalanced canal leading to a functionally univentricular heart
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• mice exhibit large inlet-type ventricular septal defect
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• mice exhibit moderately hypoplastic and anteriorly malaligned left ventricular outflow tracts
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• the right ventricular outflow tract is more posteriorly positioned than in wild-type mice
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• mice exhibit a thinning of the ventricular wall
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• at E14.5, mice exhibit systemic hemorrhage
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• proliferation of cells in the ventricular myocardium is reduced by 51% at E12.5 and 55% at E14.5 compared to in wild-type mice
• however, apoptosis rates are normal
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homeostasis/metabolism
muscle
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• fine, abnormal trabecular structures
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• at E12.5, the thickness of the ventricular compact myocardial layer is reduced 61% compared to in wild-type mice
• at E14.5, the ventricular compact myocardial layer thickness is reduced 84% compared to in wild-type mice
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• proliferation of cells in the ventricular myocardium is reduced by 51% at E12.5 and 55% at E14.5 compared to in wild-type mice
• however, apoptosis rates are normal
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cellular
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• proliferation of cells in the ventricular myocardium is reduced by 51% at E12.5 and 55% at E14.5 compared to in wild-type mice
• however, apoptosis rates are normal
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