Phenotypes associated with this allele

• Allele Symbol: Wwox^tm1.1Mald
• Allele Name: targeted mutation 1.1, Marcelo Aldaz
• Allele ID: MGI:4415792
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wwox^tm1.1Mald/Wwox^tm1.1Mald	involves: C57BL/6 * FVB/N	MGI:4415796

Genotype
MGI:4415796

hm1

• Allelic Composition: Wwox^tm1.1Mald/Wwox^tm1.1Mald
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced growth of Wwox^tm1.1Mald/Wwox^tm1.1Mald newborns

mortality/aging

postnatal lethality, complete penetrance ( J:155406 )

• 43% of mice die by 72 hours after birth, 77% of mice die by P17, and no mice survive past weaning

immune system

abnormal thymus cortex morphology ( J:155406 )

• thymic cortex thickness is reduced compared to in wild-type mice

decreased thymus weight ( J:155406 )

decreased leukocyte cell number ( J:155406 )

small spleen ( J:155406 )

decreased spleen weight ( J:155406 )

spleen atrophy ( J:155406 )

skeleton

decreased bone mineral density ( J:155406 )

decreased trabecular bone volume ( J:155406 )

• trabecular volume is decreased compared to in wild-type mice

decreased osteoblast cell number ( J:155406 )

• the number of active osteoblasts over bone surface is decreased compared to in wild-type mice

decreased bone trabecula number ( J:155406 )

• trabecular number is decreased compared to controls

decreased trabecular bone thickness ( J:155406 )

homeostasis/metabolism

increased blood urea nitrogen level ( J:155406 )

decreased circulating bicarbonate level ( J:155406 )

decreased circulating glucose level ( J:155406 )

decreased circulating calcium level ( J:155406 )

increased circulating chloride level ( J:155406 )

growth/size/body

decreased body weight ( J:155406 )

• at P14

cachexia ( J:155406 )

• by P18, mice exhibit decreased weight or multiple organs and increased brain weight consistent with wasting

postnatal growth retardation ( J:155406 )

nervous system

increased brain weight ( J:155406 )

liver/biliary system

decreased liver weight ( J:155406 )

neoplasm

neoplasm ( J:155406 )

N • unlike mice homozygous for other null alleles, mice exhibit no bone lesions compatible with osteosarcoma

hematopoietic system

abnormal thymus cortex morphology ( J:155406 )

• thymic cortex thickness is reduced compared to in wild-type mice

decreased thymus weight ( J:155406 )

anemia ( J:155406 )

• one of two mice exhibits severe anemia

decreased leukocyte cell number ( J:155406 )

small spleen ( J:155406 )

decreased spleen weight ( J:155406 )

spleen atrophy ( J:155406 )

endocrine/exocrine glands

abnormal thymus cortex morphology ( J:155406 )

• thymic cortex thickness is reduced compared to in wild-type mice

decreased thymus weight ( J:155406 )