Phenotypes associated with this allele

• Allele Symbol: Pole3^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4415417
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pole3^tm1(KOMP)Vlcg/Pole3^tm1(KOMP)Vlcg	involves: C57BL/6NTac * FVB	MGI:6491457

Genotype
MGI:6491457

hm1

• Allelic Composition: Pole3^{tm1(KOMP)Vlcg}/Pole3^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased DN4 thymocyte number ( J:298827 )

• few cells are CD44- CD25- in E16.5 embryos

increased DN3 thymocyte number ( J:298827 )

• majority of cells were CD44- CD25+ in E16.5 embryos

growth/size/body

decreased fetal size ( J:298827 )

• at age E16.5

hematopoietic system

decreased DN4 thymocyte number ( J:298827 )

• few cells are CD44- CD25- in E16.5 embryos

increased DN3 thymocyte number ( J:298827 )

• majority of cells were CD44- CD25+ in E16.5 embryos

immune system

decreased DN4 thymocyte number ( J:298827 )

• few cells are CD44- CD25- in E16.5 embryos

increased DN3 thymocyte number ( J:298827 )

• majority of cells were CD44- CD25+ in E16.5 embryos

limbs/digits/tail

short tail ( J:298827 )

• in E16.5 embryos

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:298827 )

• embryos die around age E16.5

nervous system

abnormal brain development ( J:298827 )

• severe cranial defects in E16.5 embryos

skeleton

vertebral fusion ( J:298827 )

• in E16.5 embryos

delayed bone ossification ( J:298827 )

• of rib and cranial bones in E16.5 embryos