All Phenotypes Chst1<tm1(KOMP)Vlcg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chst1^{tm1(KOMP)Vlcg}
targeted mutation 1, Velocigene
MGI:4415360

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chst1^{tm1(KOMP)Vlcg}/Chst1^{tm1(KOMP)Vlcg}	involves: C57BL/6NTac	MGI:5543505
cx2	Chst1^{tm1(KOMP)Vlcg}/Chst1^{tm1(KOMP)Vlcg} Chst2^tm1Tmu/Chst2^tm1Tmu Chst4^tm1Sdr/Chst4^tm1Sdr	involves: 129S2/SvPas * C57BL/6NTac	MGI:5543506

Allelic Composition	Chst1^{tm1(KOMP)Vlcg}/Chst1^{tm1(KOMP)Vlcg}
Genetic Background	involves: C57BL/6NTac
Cell Lines	10172A-D6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst1^{tm1(KOMP)Vlcg} mutation (2 available); any Chst1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:204813 )

N	• mice are born in Mendelian ratios

immune system

immune system phenotype ( J:204813 )

N	• lymphocyte homing is normal

decreased B cell number ( J:204813 )

• small decreased in the peripheral and mesenteric lymph nodes and peripheral blood

increased T cell number ( J:204813 )

• small increase in the peripheral lymph nodes and peripheral blood

behavior/neurological

increased aggression towards mice ( J:204813 )

• male siblings housed together seem particularly prone to fighting

hematopoietic system

decreased B cell number ( J:204813 )

• small decreased in the peripheral and mesenteric lymph nodes and peripheral blood

increased T cell number ( J:204813 )

• small increase in the peripheral lymph nodes and peripheral blood

Allelic Composition	Chst1^{tm1(KOMP)Vlcg}/Chst1^{tm1(KOMP)Vlcg} Chst2^tm1Tmu/Chst2^tm1Tmu Chst4^tm1Sdr/Chst4^tm1Sdr
Genetic Background	involves: 129S2/SvPas * C57BL/6NTac
Cell Lines	10172A-D6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst1^{tm1(KOMP)Vlcg} mutation (2 available); any Chst1 mutation (18 available)
Chst2^tm1Tmu mutation (1 available); any Chst2 mutation (23 available)
Chst4^tm1Sdr mutation (1 available); any Chst4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:204813 )

• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice

• however, homing to mesenteric lymph nodes is normal

cellular

abnormal leukocyte migration ( J:204813 )

• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice

• however, homing to mesenteric lymph nodes is normal

hematopoietic system

abnormal leukocyte migration ( J:204813 )

• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice

• however, homing to mesenteric lymph nodes is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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