Phenotypes associated with this allele

• Allele Symbol: Icos^tm1.1Wks
• Allele Name: targeted mutation 1.1, Woong-Kyung Suh
• Allele ID: MGI:4415349
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Icos^tm1.1Wks/Icos^tm1.1Wks	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4415351

Genotype
MGI:4415351

hm1

• Allelic Composition: Icos^tm1.1Wks/Icos^tm1.1Wks
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell selection ( J:155586 )

• upon immunization

abnormal B cell number ( J:155586 )

• drastic reduction in the percentage of germinal B cells relative to the total number of B cells

decreased CD4-positive, alpha-beta T cell number ( J:155586 )

• percentage of TFH (CXCR5+, ICOS+) cells reduced by 5- to 9-fold in the Peyer's patch and spleen

abnormal spleen morphology ( J:155586 )

decreased spleen germinal center number ( J:155586 )

• decreased number of germinal center B cells and germinal center foci post immunization

abnormal Peyer's patch germinal center morphology ( J:155586 )

• the germinal center area is greatly reduced

small Peyer's patches ( J:155586 )

• total cellularity of Peyer's Patches is substantially reduced

abnormal immune system physiology ( J:155586 )

abnormal B cell physiology ( J:155586 )

abnormal class switch recombination ( J:155586 )

• upon immunization

decreased IgA level ( J:155586 )

• content of secreted IgA in the feces is dramatically reduced

• but serum IgA is normal

decreased IgG1 level ( J:155586 )

• reduced to levels close to the null mouse

decreased IgG2b level ( J:155586 )

• reduced to levels close to the null mouse

decreased IgG2c level ( J:155586 )

• reduced to levels close to the null mouse

decreased interleukin-21 secretion ( J:155586 )

• expression analysis of CD4 T-cells shows decreased IL-21 in response to secondary activation

decreased interleukin-4 secretion ( J:155586 )

• expression analysis of CD4 T-cells shows decreased IL-4 in response to secondary activation

hematopoietic system

abnormal B cell selection ( J:155586 )

• upon immunization

abnormal B cell number ( J:155586 )

• drastic reduction in the percentage of germinal B cells relative to the total number of B cells

decreased CD4-positive, alpha-beta T cell number ( J:155586 )

• percentage of TFH (CXCR5+, ICOS+) cells reduced by 5- to 9-fold in the Peyer's patch and spleen

abnormal spleen morphology ( J:155586 )

decreased spleen germinal center number ( J:155586 )

• decreased number of germinal center B cells and germinal center foci post immunization

abnormal B cell physiology ( J:155586 )

abnormal class switch recombination ( J:155586 )

• upon immunization

decreased IgA level ( J:155586 )

• content of secreted IgA in the feces is dramatically reduced

• but serum IgA is normal

decreased IgG1 level ( J:155586 )

• reduced to levels close to the null mouse

decreased IgG2b level ( J:155586 )

• reduced to levels close to the null mouse

decreased IgG2c level ( J:155586 )

• reduced to levels close to the null mouse