Phenotypes associated with this allele

• Allele Symbol: Cacna1a^tm2Nobs
• Allele Name: targeted mutation 2, Noboru Suzuki
• Allele ID: MGI:4415272
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1a^tm2Nobs/Cacna1a^tm2Nobs	involves: 129 * C57BL/6J	MGI:4415279
ht2	Cacna1a^tm1Nobs/Cacna1a^tm2Nobs	involves: 129 * C57BL/6J	MGI:4415280

Genotype
MGI:4415279

hm1

• Allelic Composition: Cacna1a^tm2Nobs/Cacna1a^tm2Nobs
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:155607 )

N • mice exhibit normal a lifespan

nervous system

clonic seizures ( J:155607 )

absence seizures ( J:155607 )

abnormal spike wave discharge ( J:155607 )

cerebellum atrophy ( J:155607 )

• at 2 months, mice exhibit progressive cerebellar atrophy via apoptosis in the granular layer

behavior/neurological

ataxia ( J:155607 )

• at 10 to 12 days

impaired coordination ( J:155607 )

• mice exhibit impaired performance on a rotarod compared with wild-type mice

clonic seizures ( J:155607 )

absence seizures ( J:155607 )

abnormal spike wave discharge ( J:155607 )

Genotype
MGI:4415280

ht2

• Allelic Composition: Cacna1a^tm1Nobs/Cacna1a^tm2Nobs
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

postnatal lethality, complete penetrance ( J:155607 )

• mice die at around 3 weeks of age

nervous system

absence seizures ( J:155607 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:155607 )

• mice exhibit paroxysmal dyskinesia

ataxia ( J:155607 )

• at 10 to 12 days

absence seizures ( J:155607 )