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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr1h3tm1Wexi
targeted mutation 1, Wen Xie
MGI:4415263
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nr1h3tm1Wexi/Nr1h3tm1Wexi involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:4415266


Genotype
MGI:4415266
hm1
Allelic
Composition		 Nr1h3tm1Wexi/Nr1h3tm1Wexi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h3tm1Wexi mutation (0 available); any Nr1h3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Resistance to LPS-induced lung injury in Nr1h3tm1Wexi/Nr1h3tm1Wexi mice

immune system
decreased susceptibility to endotoxin shock ( J:155709 )
• mice exhibit resistance to LPS-induced lung injury and oxidative stress compared with similarly treated wild-type mice

liver/biliary system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory