All Phenotypes Cdx2<tm1.1Lhn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdx2^tm1.1Lhn/Cdx2^tm1.1Lhn Tg(CAG-cre/ERT2)F34Fmr/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:4415156
cn2	Cdx2^tm1.1Lhn/Cdx2⁺ Tg(CAG-cre/ERT2)F34Fmr/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:4415157

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice die around E11.5

• however, mice exposed to tamoxifen beginning at E8.5 survive to term

embryo

abnormal mesoderm development ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice lack presomitic and posterior mesoderm

short rostral-caudal axis ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice exhibit a shortened anterior posterior axis by E8.5 compared with Cdx2^tm1.1Lhn homozygotes

• when mice are exposed to tamoxifen beginning at E8.5, mice exhibit axial truncation at the level of the sacral vertebrae at E18.5

abnormal presomitic mesoderm morphology ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice lack presomitic mesoderm

absent hindlimb buds ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice fail to develop hind limb buds

decreased somite size ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, somites after the first 5 through 7 are progressively smaller than in Cdx2^tm1.1Lhn homozygotes

impaired somite development ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice have fewer, more posteriorly located somites at E9.5 and E10.5 compared with Cdx2^tm1.1Lhn homozygotes

limbs/digits/tail

absent hindlimb buds ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice fail to develop hind limb buds

Allelic Composition	Cdx2^tm1.1Lhn/Cdx2⁺ Tg(CAG-cre/ERT2)F34Fmr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx2^tm1.1Lhn mutation (0 available); any Cdx2 mutation (22 available)
Tg(CAG-cre/ERT2)F34Fmr mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

sirenomelia ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5 and 100 mg/kg body weight retinoic acid at E8.5

short tail ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5 and 10 mg/kg body weight retinoic acid at E8.5

absent tail ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5 and 100 mg/kg body weight retinoic acid at E8.5

embryo

sirenomelia ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5 and 100 mg/kg body weight retinoic acid at E8.5

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