Phenotypes associated with this allele

• Allele Symbol: Gabrg2^tm1.1Stmo
• Allele Name: targeted mutation 1.1, Stephen J Moss
• Allele ID: MGI:4415057
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabrg2^tm1.1Stmo/Gabrg2^tm1.1Stmo	B6.129S2-Gabrg2^tm1.1Stmo	MGI:4415071
ht2	Gabrg2^tm1.1Stmo/Gabrg2^+	B6.129S2-Gabrg2^tm1.1Stmo	MGI:4415072

Genotype
MGI:4415071

hm1

• Allelic Composition: Gabrg2^tm1.1Stmo/Gabrg2^tm1.1Stmo
• Genetic Background: B6.129S2-Gabrg2^tm1.1Stmo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:154745 )

• mice die prior to E10 to E14

Genotype
MGI:4415072

ht2

• Allelic Composition: Gabrg2^tm1.1Stmo/Gabrg2⁺
• Genetic Background: B6.129S2-Gabrg2^tm1.1Stmo

behavior/neurological

behavior/neurological phenotype ( J:154745 )

N • mice exhibit normal exploratory, locomotor, and anxiety-related behaviors

abnormal spatial reference memory ( J:154745 )

• mice exhibit deficits in spatial object recognition compared with wild-type mice

• however, mice exhibit normal object recognition memory

nervous system

abnormal synapse morphology ( J:154745 )

• the size of the inhibitory synapses in the CA3 region are increased compared to in wild-type mice

• however, synapses in the CA1 region are normal

abnormal miniature inhibitory postsynaptic currents ( J:154745 )

• in the CA3 hippocampal neurons, miniature inhibitory postsynaptic current (mIPSC) amplitude and frequency are increased compared to in wild-type mice

• however, mIPSCs in CA1 neurons are normal

increased miniature inhibitory postsynaptic current amplitude ( J:154745 )

• in the CA3 hippocampal neurons

increased miniature inhibitory postsynaptic current frequency ( J:154745 )

• in the CA3 hippocampal neurons