Phenotypes associated with this allele

• Allele Symbol: Stk4^tm1Dlim
• Allele Name: targeted mutation 1, Dae-Sik Lim
• Allele ID: MGI:4414818
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk4^tm1Dlim/Stk4^tm1Dlim	Not Specified	MGI:4414819
cx2	Stk3^tm1Dlim/Stk3^tm1Dlim Stk4^tm1Dlim/Stk4^tm1Dlim	Not Specified	MGI:4414821

Genotype
MGI:4414819

hm1

• Allelic Composition: Stk4^tm1Dlim/Stk4^tm1Dlim
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell number ( J:155001 )

• decrease in the number of peripheral naive T cells

abnormal T cell physiology ( J:155001 )

• display dysregulated lymphocyte trafficking

hematopoietic system

decreased T cell number ( J:155001 )

• decrease in the number of peripheral naive T cells

abnormal T cell physiology ( J:155001 )

• display dysregulated lymphocyte trafficking

Genotype
MGI:4414821

cx2

• Allelic Composition: Stk3^tm1Dlim/Stk3^tm1Dlim; Stk4^tm1Dlim/Stk4^tm1Dlim
• Genetic Background: Not Specified

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:155001 )

• die between E8.5 and E9.5

embryo

abnormal vitelline vasculature morphology ( J:155001 )

• collapse of the yolk sac vasculature by E9.5

increased embryonic tissue cell apoptosis ( J:155001 )

• in the embryonic tissue E8.5 and E9.5

increased placenta apoptosis ( J:155001 )

• at E8.5

abnormal embryo development ( J:155001 )

• deformed at E8.5

incomplete embryo turning ( J:155001 )

• at E9.5

embryonic growth retardation ( J:155001 )

• detectable by E8.5, overt by E9.5

decreased embryo size ( J:155001 )

• at E8.5

abnormal neural plate morphology ( J:155001 )

• at E8.5 - E9.0, the neural plate fails to fuse to form the neural tube and is kinked dorsoventrally

abnormal embryonic neuroepithelium morphology ( J:155001 )

• disorganized at E9.5 without any obvious boundary in the forebrain region and with a disorganized accumulation of neuroepithelial cells

decreased trophoblast giant cell number ( J:155001 )

• expression analysis suggests a decrease in the number of trophoblast giant cells

small ectoplacental cone ( J:155001 )

• suggested by expression analysis

abnormal chorion morphology ( J:155001 )

• expression analysis suggests a decrease in the number of chorion cells

abnormal placenta labyrinth morphology ( J:155001 )

• formation of the labyrinth layer is severely disrupted

abnormal placental labyrinth vasculature morphology ( J:155001 )

• vasculature is sparse and contains few embryonic erythrocytes

abnormal embryonic hematopoiesis ( J:155001 )

• yolk sacs appear to have reduced numbers of hematopoietic cells at E9.5

• cells from E8.5 yolk sacs form fewer hematopoietic colonies in culture compared to controls

abnormal placenta development ( J:155001 )

• while chorioallantoic fusion is normal formation of the labyrinth layer and all subsequent developmental steps are severely disrupted

abnormal placental transport ( J:155001 )

• transport of rhodamine dye across the placenta is reduced

nervous system

abnormal neural plate morphology ( J:155001 )

• at E8.5 - E9.0, the neural plate fails to fuse to form the neural tube and is kinked dorsoventrally

abnormal embryonic neuroepithelium morphology ( J:155001 )

• disorganized at E9.5 without any obvious boundary in the forebrain region and with a disorganized accumulation of neuroepithelial cells

cardiovascular system

abnormal blood vessel morphology ( J:155001 )

• total vascularity is decreased at E9.5

abnormal vascular endothelial cell morphology ( J:155001 )

• at E9.5

abnormal placental labyrinth vasculature morphology ( J:155001 )

• vasculature is sparse and contains few embryonic erythrocytes

abnormal angiogenesis ( J:155001 )

• at E9.5 the dorsal aorta has only primitive vasculature and the somites lack small sprouting vessels

abnormal vascular branching morphogenesis ( J:155001 )

• impaired

abnormal vitelline vasculature morphology ( J:155001 )

• collapse of the yolk sac vasculature by E9.5

abnormal heart development ( J:155001 )

• severe developmental retardation of the endocardium is detected at E9.5

cellular

increased embryonic tissue cell apoptosis ( J:155001 )

• in the embryonic tissue E8.5 and E9.5

increased placenta apoptosis ( J:155001 )

• at E8.5

abnormal cell proliferation ( J:155001 )

• disruption of the spatiotemporal pattern of cell proliferation in the embryonic tissue at E9.0 and E9.5

• however, no change in the number of proliferating cells is detected

hematopoietic system

abnormal embryonic hematopoiesis ( J:155001 )

• yolk sacs appear to have reduced numbers of hematopoietic cells at E9.5

• cells from E8.5 yolk sacs form fewer hematopoietic colonies in culture compared to controls

growth/size/body

embryonic growth retardation ( J:155001 )

• detectable by E8.5, overt by E9.5

decreased embryo size ( J:155001 )

• at E8.5