Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4tm1Dlim mutation
(0 available);
any
Stk4 mutation
(72 available)
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immune system
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• decrease in the number of peripheral naive T cells
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• display dysregulated lymphocyte trafficking
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hematopoietic system
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• decrease in the number of peripheral naive T cells
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• display dysregulated lymphocyte trafficking
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1Dlim mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4tm1Dlim mutation
(0 available);
any
Stk4 mutation
(72 available)
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mortality/aging
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• die between E8.5 and E9.5
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embryo
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• collapse of the yolk sac vasculature by E9.5
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• in the embryonic tissue E8.5 and E9.5
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• detectable by E8.5, overt by E9.5
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• at E8.5 - E9.0, the neural plate fails to fuse to form the neural tube and is kinked dorsoventrally
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• disorganized at E9.5 without any obvious boundary in the forebrain region and with a disorganized accumulation of neuroepithelial cells
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• expression analysis suggests a decrease in the number of trophoblast giant cells
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• suggested by expression analysis
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• expression analysis suggests a decrease in the number of chorion cells
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• formation of the labyrinth layer is severely disrupted
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• vasculature is sparse and contains few embryonic erythrocytes
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• yolk sacs appear to have reduced numbers of hematopoietic cells at E9.5
• cells from E8.5 yolk sacs form fewer hematopoietic colonies in culture compared to controls
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• while chorioallantoic fusion is normal formation of the labyrinth layer and all subsequent developmental steps are severely disrupted
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• transport of rhodamine dye across the placenta is reduced
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nervous system
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• at E8.5 - E9.0, the neural plate fails to fuse to form the neural tube and is kinked dorsoventrally
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• disorganized at E9.5 without any obvious boundary in the forebrain region and with a disorganized accumulation of neuroepithelial cells
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cardiovascular system
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• total vascularity is decreased at E9.5
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• vasculature is sparse and contains few embryonic erythrocytes
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• at E9.5 the dorsal aorta has only primitive vasculature and the somites lack small sprouting vessels
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• collapse of the yolk sac vasculature by E9.5
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• severe developmental retardation of the endocardium is detected at E9.5
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cellular
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• in the embryonic tissue E8.5 and E9.5
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• disruption of the spatiotemporal pattern of cell proliferation in the embryonic tissue at E9.0 and E9.5
• however, no change in the number of proliferating cells is detected
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hematopoietic system
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• yolk sacs appear to have reduced numbers of hematopoietic cells at E9.5
• cells from E8.5 yolk sacs form fewer hematopoietic colonies in culture compared to controls
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growth/size/body
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• detectable by E8.5, overt by E9.5
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Analysis Tools