Analysis Tools
cardiovascular system
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• following myocardial ischemia and reperfusion injury, mice exhibit less of a decreased in fractional shortening compared with similarly treated wild-type mice
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• following myocardial ischemia and reperfusion injury, mice exhibit less of a decreased in fractional shortening, less of an increase in left ventricle end-systolic dimensions, and reduced neutrophil accumulation and myeoloperoxidase activity in ischemic myocardium compared with similarly treated wild-type mice
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• following myocardial ischemia and reperfusion injury, mice exhibit decreased infarction size compared with similarly treated wild-type mice
• following myocardial ischemia and reperfusion injury, lethally irradiated wild-type mice reconstituted with bone marrow exhibit smaller infarction size compared with mice reconstituted with wild-type bone marrow
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immune system
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• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal edema
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• following myocardial ischemia and reperfusion injury, mice exhibit reduced neutrophil accumulation and myeoloperoxidase activity in ischemic myocardium compared with similarly treated wild-type mice
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• C5a-, fMLP-, or A23187-stimulated neutrophils exhibit lower respiratory-burst compared with similarly treated wild-type cells
• neutrophils release less elastase in response to serum-opsonized zymosan compared with similarly treated wild-type cells
• neutrophil extracellular release of arachidonic acid in response to C5a of fMLP is lower than similarly treated wild-type cells
• however, neutrophil physiology in response to arachidonic acid and PMA is normal
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• in C5a-, fMLP-, or A23187-stimulated neutrophils
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homeostasis/metabolism
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• following myocardial ischemia and reperfusion injury, mice exhibit less of a decreased in fractional shortening, less of an increase in left ventricle end-systolic dimensions, and reduced neutrophil accumulation and myeoloperoxidase activity in ischemic myocardium compared with similarly treated wild-type mice
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• following myocardial ischemia and reperfusion injury, mice exhibit decreased infarction size compared with similarly treated wild-type mice
• following myocardial ischemia and reperfusion injury, lethally irradiated wild-type mice reconstituted with bone marrow exhibit smaller infarction size compared with mice reconstituted with wild-type bone marrow
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muscle
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• following myocardial ischemia and reperfusion injury, mice exhibit less of a decreased in fractional shortening compared with similarly treated wild-type mice
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hematopoietic system
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• following myocardial ischemia and reperfusion injury, mice exhibit reduced neutrophil accumulation and myeoloperoxidase activity in ischemic myocardium compared with similarly treated wild-type mice
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• C5a-, fMLP-, or A23187-stimulated neutrophils exhibit lower respiratory-burst compared with similarly treated wild-type cells
• neutrophils release less elastase in response to serum-opsonized zymosan compared with similarly treated wild-type cells
• neutrophil extracellular release of arachidonic acid in response to C5a of fMLP is lower than similarly treated wild-type cells
• however, neutrophil physiology in response to arachidonic acid and PMA is normal
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• in C5a-, fMLP-, or A23187-stimulated neutrophils
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cellular
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• in C5a-, fMLP-, or A23187-stimulated neutrophils
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