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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nkx6-2tm1(cre/ERT2)Fsh
targeted mutation 1, Gordon Fishell
MGI:4412372
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nkx6-2tm1(cre/ERT2)Fsh/Nkx6-2tm1(cre/ERT2)Fsh involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster MGI:4412376
cn2
 		Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Gt(ROSA)26Sor+
Nkx6-2tm1Qiu/Nkx6-2tm1(cre/ERT2)Fsh 		involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster MGI:4412378


Genotype
MGI:4412376
hm1
Allelic
Composition		 Nkx6-2tm1(cre/ERT2)Fsh/Nkx6-2tm1(cre/ERT2)Fsh
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-2tm1(cre/ERT2)Fsh mutation (1 available); any Nkx6-2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:155164 )
N
• mice are born in normal Mendelian ratios and survive to adulthood similar to Nkx6-2tm1Qiu homozygotes




Genotype
MGI:4412378
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Gt(ROSA)26Sor+
Nkx6-2tm1Qiu/Nkx6-2tm1(cre/ERT2)Fsh
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Nkx6-2tm1(cre/ERT2)Fsh mutation (1 available); any Nkx6-2 mutation (16 available)
Nkx6-2tm1Qiu mutation (0 available); any Nkx6-2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain interneuron morphology ( J:155164 )
• following tamoxifen treatment at E12.5, mice exhibit a small and partially penetrant loss of delayed non-fast spiking somatostatin/calretinin double positive cortical interneurons compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory