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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
targeted mutation 2, Jeremy Nathans
MGI:4412094
Summary 4 genotypes


Genotype
MGI:4412194
cn1
Allelic
Composition		 Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat mutation (1 available); any Igs1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:154020 )
• Background Sensitivity: mid-gestational lethality

growth/size/body
embryonic growth retardation ( J:154020 )
• Background Sensitivity: growth retardation at E10.5

cardiovascular system
abnormal aorta smooth muscle morphology ( J:154020 )
• Background Sensitivity: no visceral smooth muscle associated with the aorta at E9.5
abnormal angiogenesis ( J:154020 )
• Background Sensitivity: severely disrupted

embryo
embryonic growth retardation ( J:154020 )
• Background Sensitivity: growth retardation at E10.5

muscle
abnormal aorta smooth muscle morphology ( J:154020 )
• Background Sensitivity: no visceral smooth muscle associated with the aorta at E9.5




Genotype
MGI:4412195
cn2
Allelic
Composition		 Fzd4tm1Nat/Fzd4+
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (33 available)
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat mutation (1 available); any Igs1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, incomplete penetrance ( J:154020 )
• Background Sensitivity: mid-gestational lethality but some survival to E18

growth/size/body
embryonic growth retardation ( J:154020 )
• Background Sensitivity: growth retardation moderated

cardiovascular system
abnormal descending aorta morphology ( J:154020 )
• Background Sensitivity: disruption less severe
abnormal angiogenesis ( J:154020 )
• Background Sensitivity: less severely disrupted

embryo
embryonic growth retardation ( J:154020 )
• Background Sensitivity: growth retardation moderated




Genotype
MGI:4412196
cn3
Allelic
Composition		 Fzd4tm1Nat/Fzd4tm1Nat
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (33 available)
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat mutation (1 available); any Igs1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:154020 )
N
• Background Sensitivity: normal survival

growth/size/body
growth/size/body region phenotype ( J:154020 )
N
• Background Sensitivity: normal phenotype

cardiovascular system
cardiovascular system phenotype ( J:154020 )
N
• Background Sensitivity: normal phenotype




Genotype
MGI:4412197
cn4
Allelic
Composition		 Lrp5tm1Kry/Lrp5tm1Kry
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat mutation (1 available); any Igs1 mutation (10 available)
Lrp5tm1Kry mutation (0 available); any Lrp5 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, incomplete penetrance ( J:154020 )
• Background Sensitivity: mid-gestational lethality but some survival improvement

growth/size/body
embryonic growth retardation ( J:154020 )
• Background Sensitivity: growth retardation moderated

cardiovascular system
abnormal descending aorta morphology ( J:154020 )
• Background Sensitivity: disruption less severe
abnormal angiogenesis ( J:154020 )
• Background Sensitivity: less severely disrupted

embryo
embryonic growth retardation ( J:154020 )
• Background Sensitivity: growth retardation moderated




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory