Analysis Tools
reproductive system
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• litter size is consistently small (3-5 pups).
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immune system
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• neutrophils respond to formyl-Met-Leu-Phe, by forming multiple lateral pseudopods instead of the single clearly-defined leading or trailing edge pseudopod
• about 80% of wild-type neutrophils orient their microtubules toward the back of the cel upon stimulation compared to only approximately 11% of homozygous null neutrophils
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• a reduced number of neutrophils migrate through the filter into the lower chamber of a transwell device, especially at higher concentrations of formyl-Met-Leu-Phe
• null neutrophils eventually migrate toward a micropipette point-source of chemoattractant,
but take circuitous routes to reach it
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cellular
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• a reduced number of neutrophils migrate through the filter into the lower chamber of a transwell device, especially at higher concentrations of formyl-Met-Leu-Phe
• null neutrophils eventually migrate toward a micropipette point-source of chemoattractant,
but take circuitous routes to reach it
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hematopoietic system
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• neutrophils respond to formyl-Met-Leu-Phe, by forming multiple lateral pseudopods instead of the single clearly-defined leading or trailing edge pseudopod
• about 80% of wild-type neutrophils orient their microtubules toward the back of the cel upon stimulation compared to only approximately 11% of homozygous null neutrophils
|
|
|
• a reduced number of neutrophils migrate through the filter into the lower chamber of a transwell device, especially at higher concentrations of formyl-Met-Leu-Phe
• null neutrophils eventually migrate toward a micropipette point-source of chemoattractant,
but take circuitous routes to reach it
|
