Phenotypes associated with this allele

• Allele Symbol: Zfp24^hmcns
• Allele Name: hypomyelinated central nervous system
• Allele ID: MGI:4412036
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp24^hmcns/Zfp24^hmcns	C3.Cg-a Zfp24^hmcns/GrsrJ	MGI:4429672
ht2	Zfp24^hmcns/Zfp24^tm1.2Pop	involves: 129S4/SvJae * C3H/HeJ * C57BL/6	MGI:4429674

Genotype
MGI:4429672

hm1

• Allelic Composition: Zfp24^hmcns/Zfp24^hmcns
• Genetic Background: C3.Cg-a Zfp24^hmcns/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:156938 )

• die by P25

behavior/neurological

tremors ( J:156938 )

• at P14

tonic seizures ( J:156938 )

• at P14

nervous system

tonic seizures ( J:156938 )

• at P14

decreased oligodendrocyte number ( J:156938 )

• reduced number of post-mitotic and myelinating oligodendrocytes in the brainstem

decreased brain size ( J:156938 )

abnormal myelin sheath morphology ( J:156938 )

• myelin deficiency in the central nervous system, however axons in the peripheral nervous system are normally myelinated

• rare myelin sheaths in central nervous system are thinner

abnormal spinal cord white matter morphology ( J:156938 )

• apparent lack of white matter at P14

decreased spinal cord size ( J:156938 )

cellular

decreased oligodendrocyte number ( J:156938 )

• reduced number of post-mitotic and myelinating oligodendrocytes in the brainstem

Genotype
MGI:4429674

ht2

• Allelic Composition: Zfp24^hmcns/Zfp24^tm1.2Pop
• Genetic Background: involves: 129S4/SvJae * C3H/HeJ * C57BL/6

behavior/neurological

tremors ( J:156938 )

nervous system

abnormal myelin sheath morphology ( J:156938 )

• severe hypomyelination in the CNS