Analysis Tools
behavior/neurological
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• mice exhibit normal fear conditioning, motor function and learning, and spatial working memory
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• in an open field test, mice between 1.5 and 6 months of age spend more time in the center of the field compared with wild-type mice
• in a light-dark test, mice between 1.5 and 6 months of age spend more time in the light compartment compared with wild-type mice
• in an elevated plus maze, mice between 1.5 and 6 months of age spend more time in the open arms compared to wild-type mice
• mice exhibit impaired anxiety-related cognition compared with wild-type mice
• however, treatment with PBA (4-phenylbutyric acid) rescues impaired anxiety-related cognition
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• in a novel object recognition test, the reduction in exploration of an object in a second trial is not as great as for wild-type mice
• mice exhibit impaired anxiety-related cognition compared with wild-type mice
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