Phenotypes associated with this allele

• Allele Symbol: Sin3b^tm1.2Rdp
• Allele Name: targeted mutation 1.2 Ronald dePinho
• Allele ID: MGI:4410336
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sin3b^tm1.2Rdp/Sin3b^tm1.2Rdp	involves: 129 * C57BL/6 * FVB/N * SJL	MGI:4410372

Genotype
MGI:4410372

hm1

• Allelic Composition: Sin3b^tm1.2Rdp/Sin3b^tm1.2Rdp
• Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:154855 )

• fail to survive beyond the first day after birth

growth/size/body

decreased fetal weight ( J:154855 )

• E17.5 embryos weigh 40% less than controls

fetal growth retardation ( J:154855 )

• retardation observed by E14.5

liver/biliary system

pale liver ( J:154855 )

• after E14

hematopoietic system

abnormal granulocyte differentiation ( J:154855 )

• increased abundance of granulocyte progenitors in the fetal liver

increased erythroid progenitor cell number ( J:154855 )

• in the fetal liver

abnormal erythrocyte morphology ( J:154855 )

decreased erythrocyte cell number ( J:154855 )

• reduced number of circulating red blood cells at E18.5

decreased hemoglobin content ( J:154855 )

• reduced hemoglobin levels at E18.5

increased nucleated erythrocyte cell number ( J:154855 )

• immature nucleated erythrocytes in circulating blood smears at E18.5

increased number of Howell-Jolly bodies ( J:154855 )

• erythrocytes with nuclear fragments (Howell-Jolly bodies) at E18.5

decreased granulocyte number ( J:154855 )

• reduced numbers of mature granulocytes in bone marrow at E18.5

skeleton

abnormal bone mineralization ( J:154855 )

• significant reduction in bone deposition

• decreased bone/cartillage ratio in hind limbs

cellular

abnormal cell cycle checkpoint function ( J:154855 )

• impaired G0 arrest in MEFs under low serum conditions

abnormal granulocyte differentiation ( J:154855 )

• increased abundance of granulocyte progenitors in the fetal liver

immune system

abnormal granulocyte differentiation ( J:154855 )

• increased abundance of granulocyte progenitors in the fetal liver

decreased granulocyte number ( J:154855 )

• reduced numbers of mature granulocytes in bone marrow at E18.5