Phenotypes associated with this allele

• Allele Symbol: Spdef^tm1.2Cle
• Allele Name: targeted mutation 1.2, Hans Clevers
• Allele ID: MGI:4410321
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spdef^tm1.2Cle/Spdef^tm1.2Cle	involves: 129P2/OlaHsd * FVB/N	MGI:4410332

Genotype
MGI:4410332

hm1

• Allelic Composition: Spdef^tm1.2Cle/Spdef^tm1.2Cle
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:154852 )

• fewer goblet cells are detected by PAS reactivity in the small intestine and colon compared to in wild-type mice

• some goblet cells exhibit abnormal morphology compared with wild-type cells

• immature goblet cells accumulate in crypts unlike in wild-type mice

• actively secreting goblet cells are infrequently observed unlike in wild-type mice

abnormal crypts of Lieberkuhn morphology ( J:154852 )

• crypts exhibit reduced Paneth cell compartment and granuole content compared to in wild-type mice

• however, the number of enteroendocrine cells is normal

abnormal Paneth cell morphology ( J:154852 )

• Paneth cells contain fewer granular vacuoles compared with wild-type cells

decreased Paneth cell number ( J:154852 )

• the number of Paneth cells per crypt is reduced 1.9- and 1.8-fold in the proximal and distal intestine, respectively, compared to in wild-type mice

• occasionally crypts lack Paneth cells unlike in wild-type mice

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:154852 )

• crypts exhibit reduced Paneth cell compartment and granuole content compared to in wild-type mice

• however, the number of enteroendocrine cells is normal

abnormal Paneth cell morphology ( J:154852 )

• Paneth cells contain fewer granular vacuoles compared with wild-type cells

decreased Paneth cell number ( J:154852 )

• the number of Paneth cells per crypt is reduced 1.9- and 1.8-fold in the proximal and distal intestine, respectively, compared to in wild-type mice

• occasionally crypts lack Paneth cells unlike in wild-type mice

cellular

abnormal intestinal goblet cell morphology ( J:154852 )

• fewer goblet cells are detected by PAS reactivity in the small intestine and colon compared to in wild-type mice

• some goblet cells exhibit abnormal morphology compared with wild-type cells

• immature goblet cells accumulate in crypts unlike in wild-type mice

• actively secreting goblet cells are infrequently observed unlike in wild-type mice