Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efemp2tm1.2Tynk mutation
(0 available);
any
Efemp2 mutation
(26 available)
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mortality/aging
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• mice die shortly after birth
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cardiovascular system
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• the aorta is tortuous unlike in wild-type mice
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• the aortic elastic laminae is complete disarranged
• the elastogenesis is abolished
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muscle
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efemp2tm1.1Tynk mutation
(0 available);
any
Efemp2 mutation
(26 available)
Efemp2tm1.2Tynk mutation
(0 available);
any
Efemp2 mutation
(26 available)
Tg(Tagln-cre)1Her mutation
(2 available)
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cardiovascular system
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• at P0, the aortic laminae is disrupted unlike in wild-type mice
• at P14, the elastic laminae is disrupted unlike in wild-type mice
• at 12 weeks, aorta are less distensible than in wild-type mice
• mice loss the internal elastic lamina in the ascending aorta unlike wild-type mice
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• severe ascending aortic aneurysms
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• the ascending aorta from the aortic root to just distal to the branching point of the brachiocephalic artery is dilated
• however, no aortic stenosis is observed
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• at 12 weeks, aorta are less distensible and stiffer than in wild-type mice
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growth/size/body
muscle
Analysis Tools