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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prr7tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:4399196
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Prr7tm1(KOMP)Vlcg/Prr7tm1(KOMP)Vlcg involves: C57BL/6NTac MGI:5817016


Genotype
MGI:5817016
hm1
Allelic
Composition
Prr7tm1(KOMP)Vlcg/Prr7tm1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6NTac
Cell Lines 10972A-A8
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prr7tm1(KOMP)Vlcg mutation (1 available); any Prr7 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice show no major defects in the development of most T cell subpopulations, B cells, NK cells or NK T cells, and exhibit normal pathogen control and T cell response to L. monocytogenes infection as well as normal T cell effector functions following induction of experimental autoimmune encephalomyelitis
• in vitro, stimulated T cells show normal CD69 upregulation and retain ability to proliferate and activate induced cell death programs
• mice show a slight but significant decrease in the number of single positive CD4+ T cells in the thymus
• however, no decrease in CD4+ T cells is noted in periphery (spleen, lymph nodes)

hematopoietic system
• mice show a slight but significant decrease in the number of single positive CD4+ T cells in the thymus
• however, no decrease in CD4+ T cells is noted in periphery (spleen, lymph nodes)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory