All Phenotypes Bcl9l<tm1.1Agt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bcl9l^tm1.1Agt
targeted mutation 1.1, Michel Aguet
MGI:4398981

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bcl9^tm1.1Agt/Bcl9^tm1.1Agt Bcl9l^tm1.1Agt/Bcl9l^tm1.1Agt Myf5^tm1(cre)Mrc/Myf5⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	MGI:4399036

Allelic Composition	Bcl9^tm1.1Agt/Bcl9^tm1.1Agt Bcl9l^tm1.1Agt/Bcl9l^tm1.1Agt Myf5^tm1(cre)Mrc/Myf5⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl9l^tm1.1Agt mutation (1 available); any Bcl9l mutation (40 available)
Bcl9^tm1.1Agt mutation (1 available); any Bcl9 mutation (47 available)
Myf5^tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle development ( J:154476 )

• myogenic differentiation is impaired in vitro and during regeneration even in the presence of exogenous Wnt3a

decreased skeletal muscle fiber size ( J:154476 )

• after injury

impaired skeletal muscle regeneration ( J:154476 )

• skeletal muscle regeneration is impaired 4 and 6 days after injury with reduced average fiber size and number of regenerating fibers per field of injury and increased apoptosis compared to in similarly treated wild-type mice

• myogenic differentiation during regeneration is inhibited even in the presence of exogenous Wnt3a

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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