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Allele Symbol Allele Name Allele ID |
Acvrl1tm2Spo targeted mutation 2, S Paul Oh MGI:4398904 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die at E18.5
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• the vascular smooth muscle cell layers of the dorsal aorta are more compact than in wild-type mice
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• lung vasculature are dilated, tortuous, and irregular unlike in wild-type mice
• lung blood vessels exhibit thinning and irregular vascular smooth muscle cell layers compared to in wild-type mice
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• from E15.5 to E17.5, yolk sac blood vessels bulge and are larger than the umbilical vessels unlike in wild-type mice
• extraembryonic vessels exhibit increased lumen diameter and decreased wall thickness compared to in wild-type vessels
• vitelline vessels are dilated, convoluted, tortuous, and also make abnormal direct connections between arteries and veins without connecting capillary beds unlike wild-type vessels
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• the vascular smooth muscle cell layers of the pulmonary vessels, vitelline vessels, and the dorsal aorta are more compact than in wild-type mice
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• vitelline vessels are dilated, convoluted, tortuous, and also make abnormal direct connections between arteries and veins without connecting capillary beds unlike wild-type vessels
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• pulmonary and vitelline vessels
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• from E15.5 to E17.5, yolk sac blood vessels bulge and are larger than the umbilical vessels unlike in wild-type mice
• extraembryonic vessels exhibit increased lumen diameter and decreased wall thickness compared to in wild-type vessels
• vitelline vessels are dilated, convoluted, tortuous, and also make abnormal direct connections between arteries and veins without connecting capillary beds unlike wild-type vessels
|
|
• lung vasculature are dilated, tortuous, and irregular unlike in wild-type mice
• lung blood vessels exhibit thinning and irregular vascular smooth muscle cell layers compared to in wild-type mice
|
|
• the vascular smooth muscle cell layers of the pulmonary vessels, vitelline vessels, and the dorsal aorta are more compact than in wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hereditary hemorrhagic telangiectasia | DOID:1270 |
OMIM:187300 OMIM:600376 OMIM:601101 OMIM:615506 |
J:130020 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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