Phenotypes associated with this allele

• Allele Symbol: Spdef^tm1.1Cle
• Allele Name: targeted mutation 1.1, Hans Clevers
• Allele ID: MGI:4398888
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spdef^tm1.1Cle/Spdef^tm1.1Cle	involves: 129P2/OlaHsd	MGI:4410329

Genotype
MGI:4410329

hm1

• Allelic Composition: Spdef^tm1.1Cle/Spdef^tm1.1Cle
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Absence of mucous (goblet) cells in tracheal and laryngeal submucosal glands in Spdef^tm1.1Cle/Spdef^tm1.1Cle mice

respiratory system

abnormal laryngeal mucosa goblet cell morphology ( J:154639 )

• goblet cells are absent from the laryngeal submucosal glands unlike in wild-type mice

absent respiratory mucosa goblet cells ( J:154639 )

• goblet cells are absent from the tracheal and laryngeal submucosal glands unlike in wild-type mice

• ovalbumin sensitized mice lack goblet cells in the bronchial-bronchiolar epithelium unlike similarly treated heterozygous mice