Phenotypes associated with this allele

• Allele Symbol: Khk^tm2Dtb
• Allele Name: targeted mutation 2, David T Bonthron
• Allele ID: MGI:4398729
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Khk^tm2Dtb/Khk^tm2Dtb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4398733

Genotype
MGI:4398733

hm1

• Allelic Composition: Khk^tm2Dtb/Khk^tm2Dtb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:166959 , J:182240 )

N • mice exhibit normal blood chemistry and tissue metabolite levels (J:166959)

♂N • 2-month-old mice show no differences in body weight, liver, and epididymal fat weight, blood pressure, or biochemical analyses at baseline (J:182240)

abnormal blood homeostasis ( J:182240 )

♂ • mice show higher baseline serum fructose levels

♂ • serum fructose levels increase further with high fructose intake

decreased energy expenditure ( J:182240 )

♂ • mice fed 30% fructose show reduced total energy expenditure than wild-type mice

increased liver glycogen level ( J:182240 )

♂ • fructose-fed mice have much more glycogen accumulation in the liver than wild-type mice

abnormal urine homeostasis ( J:182240 )

♂ • urinary fructose is elevated in fructose-fed mice

abnormal metabolism ( J:182240 )

♂ • mice fed 30% fructose are protected from the metabolic effects of fructose, showing complete protection from the increases in weight gain, total body fat, epididymal fat, serum insulin, serum leptin, serum LDL cholesterol, hepatic FAS expression, and hepatic steatosis that are seen in wild-type mice fed 15% fructose

behavior/neurological

abnormal liquid preference ( J:182240 )

♂ • mice do not show a preference for fructose water over normal water

abnormal food intake ( J:182240 )

♂ • mice given 30% fructose receive 32.4% of their total energy intake as fructose compared to wild-type mice which receive 45%, indicating lower cumulative energy intake as fructose and increased as chow

reproductive system

reproductive system phenotype ( J:166959 )

N • mice exhibit normal fertility

liver/biliary system

abnormal liver morphology ( J:182240 )

♂ • mice fed 30% fructose show higher intrahepatic uric acid levels and lower intrahepatic phosphate levels than wild-type mice

increased liver glycogen level ( J:182240 )

♂ • fructose-fed mice have much more glycogen accumulation in the liver than wild-type mice

decreased susceptibility to hepatic steatosis ( J:182240 )

♂ • mice fed 30% fructose show complete protection from hepatic steatosis that is seen in wild-type mice fed 15% fructose

embryo

embryo phenotype ( J:166959 )

N • mice exhibit normal development

renal/urinary system

abnormal urine homeostasis ( J:182240 )

♂ • urinary fructose is elevated in fructose-fed mice