Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fgf10Mhdaaey17 Martin Hrabe de Angelis abnormalities of the eye 17 MGI:4398706 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous mutant mice are not viable because of major developmental defects
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• in some mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal eye size, cornea, lens, and viterous
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• at E17.5, lens nuclei are not distributed on the central lens area unlike in wild-type mice
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• thickened at E17.5
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• swollen at E17.5
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• at E17.5 but not at later time points
(J:154551)
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• the Harderian gland is severely reduced and is seen as a fibrotic, pigmented mass with only a few remaining alveoli lined by epithelial cells with cytoplasmic fat vacuoles (foamy cells) unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P1, some mice exhibit bulges in the retina unlike in wild-type mice
• however, eyes are normal at P7
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• at P7, lens fiber cell nuclei are more diffuse compared to in wild-type mice
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• at P1, some mice exhibit bulges in the retina unlike in wild-type mice
• however, eyes are normal at P7
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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