Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fgf10Mhdaaey17 Martin Hrabe de Angelis abnormalities of the eye 17 MGI:4398706 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• homozygous mutant mice are not viable because of major developmental defects
|
|
• in some mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal eye size, cornea, lens, and viterous
|
|
• at E17.5, lens nuclei are not distributed on the central lens area unlike in wild-type mice
|
|
• thickened at E17.5
|
|
• swollen at E17.5
|
|
• at E17.5 but not at later time points
(J:154551)
|
|
• the Harderian gland is severely reduced and is seen as a fibrotic, pigmented mass with only a few remaining alveoli lined by epithelial cells with cytoplasmic fat vacuoles (foamy cells) unlike in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at P1, some mice exhibit bulges in the retina unlike in wild-type mice
• however, eyes are normal at P7
|
|
• at P7, lens fiber cell nuclei are more diffuse compared to in wild-type mice
|
|
• at P1, some mice exhibit bulges in the retina unlike in wild-type mice
• however, eyes are normal at P7
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 03/25/2025 MGI 6.24 |
|
|
|
||
