All Phenotypes Fgf10<Mhdaaey17> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgf10^Mhdaaey17
Martin Hrabe de Angelis abnormalities of the eye 17
MGI:4398706

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf10^Mhdaaey17/Fgf10^Mhdaaey17	C3HeB/FeJ-Fgf10^Mhdaaey17	MGI:4398723
ht2	Fgf10^Mhdaaey17/Fgf10⁺	C3HeB/FeJ-Fgf10^Mhdaaey17	MGI:4398721
ht3	Fgf10^Mhdaaey17/Fgf10⁺	involves: C3HeB/FeJ * C57BL/6	MGI:4398722

Allelic Composition	Fgf10^Mhdaaey17/Fgf10^Mhdaaey17
Genetic Background	C3HeB/FeJ-Fgf10^Mhdaaey17

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^Mhdaaey17 mutation (1 available); any Fgf10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:154551 )

• homozygous mutant mice are not viable because of major developmental defects

limbs/digits/tail

absent limbs ( J:154551 )

• in some mice

Allelic Composition	Fgf10^Mhdaaey17/Fgf10⁺
Genetic Background	C3HeB/FeJ-Fgf10^Mhdaaey17

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^Mhdaaey17 mutation (1 available); any Fgf10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:154551 )

N	• mice exhibit normal eye size, cornea, lens, and viterous

abnormal lens morphology ( J:154551 )

• at E17.5, lens nuclei are not distributed on the central lens area unlike in wild-type mice

abnormal lens epithelium morphology ( J:154551 )

• thickened at E17.5

abnormal lens fiber morphology ( J:154551 )

• swollen at E17.5

microphthalmia ( J:86685 , J:154551 )

• at E17.5 but not at later time points (J:154551)

narrow eye opening ( J:154551 )

endocrine/exocrine glands

Harderian gland atrophy ( J:154551 )

• the Harderian gland is severely reduced and is seen as a fibrotic, pigmented mass with only a few remaining alveoli lined by epithelial cells with cytoplasmic fat vacuoles (foamy cells) unlike in wild-type mice

Allelic Composition	Fgf10^Mhdaaey17/Fgf10⁺
Genetic Background	involves: C3HeB/FeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10^Mhdaaey17 mutation (1 available); any Fgf10 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina apoptosis ( J:154551 )

• at P1, some mice exhibit bulges in the retina unlike in wild-type mice

• however, eyes are normal at P7

abnormal lens fiber morphology ( J:154551 )

• at P7, lens fiber cell nuclei are more diffuse compared to in wild-type mice

cellular

abnormal retina apoptosis ( J:154551 )

• at P1, some mice exhibit bulges in the retina unlike in wild-type mice

• however, eyes are normal at P7

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