Phenotypes associated with this allele

• Allele Symbol: Lnpep^tm1.1Sych
• Allele Name: targeted mutation 1.1, Siew Yeen Chai
• Allele ID: MGI:4397580
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lnpep^tm1.1Sych/Lnpep^tm1.1Sych	involves: BALB/cJ * C57BL/6	MGI:4397583

Genotype
MGI:4397583

hm1

• Allelic Composition: Lnpep^tm1.1Sych/Lnpep^tm1.1Sych
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:154386 )

N • mice exhibit normal novel object recognition, anxiety-related behaviors, locomotion, sensory perception, reflexes, and vestibular function

abnormal spatial working memory ( J:154386 )

• at 6 months, mice in a Y-maze spend less time in the novel arm compared with wild-type mice

• however, mice exhibit normal behavior in a Y-maze at 4 and 12 months of age

impaired coordination ( J:154386 )

• 3 months, mice exhibit a significantly greater tendency to fall from an accelerating rotarod compared with wild-type mice

• however, mice exhibit normal performance on a rotarod at 6 and 12 months of age