Phenotypes associated with this allele

• Allele Symbol: Ppp1r9a^tm1Pggd
• Allele Name: targeted mutation 1, Paul Greengard
• Allele ID: MGI:4397456
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp1r9a^tm1Pggd/Ppp1r9a^tm1Pggd	involves: 129/SvEv * C57BL/6	MGI:4430313

Genotype
MGI:4430313

hm1

• Allelic Composition: Ppp1r9a^tm1Pggd/Ppp1r9a^tm1Pggd
• Genetic Background: involves: 129/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron physiology ( J:110264 )

• alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor responses in striatal neurons and pyramidal neurons isolated from prefrontal cortex are unaffected by dopamine D1 receptor agonist, SKF 81297

increased excitatory postsynaptic current frequency ( J:110264 )

• the frequency of spontaneous excitatory postsynaptic currents is significantly higher

• 10 uM quinpirole reduces the frequency of spontaneous excitatory postsynaptic currents

reduced long-term potentiation ( J:110264 )

• high-frequency stimulation of corticostriatal terminals fails to produce long term potentiation (LTP)

• bathing cells in a dopamine D1 like receptor agonist (SKF 38393) restores corticostriatal LTP

abnormal miniature excitatory postsynaptic currents ( J:110264 )

• the frequency of miniature excitatory postsynaptic currents in the presence of 1 uM tetrodotoxin is significantly higher

behavior/neurological

enhanced behavioral response to cocaine ( J:110264 )

• mice are more sensitive to the acute locomotor activating effects of cocaine