All Phenotypes Usp36<Gt(EUCE00141e03)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Usp36^{Gt(EUCE00141e03)Hmgu}
gene trap EUCE00141e03, Helmholtz Zentrum Muenchen GmbH
MGI:4378382

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp36^{Gt(EUCE00141e03)Hmgu}/Usp36^{Gt(EUCE00141e03)Hmgu}	involves: 129P2/OlaHsd * C57BL/6	MGI:6121448

Allelic Composition	Usp36^{Gt(EUCE00141e03)Hmgu}/Usp36^{Gt(EUCE00141e03)Hmgu}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp36^{Gt(EUCE00141e03)Hmgu} mutation (0 available); any Usp36 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:257189 )

• homozygous embryos are detected at the morula stage (E2.5) but absent at the blastocyst stage

embryo

increased embryonic tissue cell apoptosis ( J:257189 )

• 4 of 4 arrested morula show markers for apoptosis

failure of blastocyst formation ( J:257189 )

• cultured embryos collected at E2.5 fail to progress past the morula stage

embryonic growth arrest ( J:257189 )

• arrest at the morula stage

cellular

abnormal cell physiology ( J:257189 )

• results from embryos and MEFS suggest that mRNA translation and rRNA synthesis are impaired

increased embryonic tissue cell apoptosis ( J:257189 )

• 4 of 4 arrested morula show markers for apoptosis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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