Phenotypes associated with this allele

• Allele Symbol: Usp36^{Gt(EUCE00141e03)Hmgu}
• Allele Name: gene trap EUCE00141e03, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4378382
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp36^Gt(EUCE00141e03)Hmgu/Usp36^Gt(EUCE00141e03)Hmgu	involves: 129P2/OlaHsd * C57BL/6	MGI:6121448

Genotype
MGI:6121448

hm1

• Allelic Composition: Usp36^{Gt(EUCE00141e03)Hmgu}/Usp36^{Gt(EUCE00141e03)Hmgu}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:257189 )

• homozygous embryos are detected at the morula stage (E2.5) but absent at the blastocyst stage

embryo

increased embryonic tissue cell apoptosis ( J:257189 )

• 4 of 4 arrested morula show markers for apoptosis

failure of blastocyst formation ( J:257189 )

• cultured embryos collected at E2.5 fail to progress past the morula stage

embryonic growth arrest ( J:257189 )

• arrest at the morula stage

cellular

abnormal cell physiology ( J:257189 )

• results from embryos and MEFS suggest that mRNA translation and rRNA synthesis are impaired

increased embryonic tissue cell apoptosis ( J:257189 )

• 4 of 4 arrested morula show markers for apoptosis