Phenotypes associated with this allele

• Allele Symbol: Aplnr^tm1.1Tq
• Allele Name: targeted mutation 1.1, Thomas Quertermous
• Allele ID: MGI:4367882
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aplnr^tm1.1Tq/Aplnr^tm1.1Tq	C57BL/6-Aplnr^tm1.1Tq	MGI:4367885
ht2	Aplnr^tm1.1Tq/Aplnr^+	C57BL/6-Aplnr^tm1.1Tq	MGI:4367884

Genotype
MGI:4367885

hm1

• Allelic Composition: Aplnr^tm1.1Tq/Aplnr^tm1.1Tq
• Genetic Background: C57BL/6-Aplnr^tm1.1Tq

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:154303 )

• fewer than expected mice are produced from heterozygous parents even when the deficit of maternal care is corrected with fostering

cardiovascular system

abnormal heart development ( J:154303 )

• some embryos exhibit cardiac development defects unlike wild-type mice

decreased cardiac muscle contractility ( J:154303 )

• mice exhibit decreased fractional shortening compared with wild-type mice

abnormal myocardial fiber physiology ( J:154303 )

• cardiomyocyte sarcomeric function is decreased with impaired velocity of contraction and relaxation compared to in wild-type mice

• however, intracellular calcium is unchanged

homeostasis/metabolism

impaired exercise endurance ( J:154303 )

• mice exhibit decreased exercise endurance compared with wild-type mice

behavior/neurological

abnormal maternal behavior ( J:154303 )

♀ • poor maternal care is more pronounced than in heterozygous mice

impaired exercise endurance ( J:154303 )

• mice exhibit decreased exercise endurance compared with wild-type mice

embryo

embryonic growth arrest ( J:154303 )

• some embryos exhibit evidence of overall developmental failure

muscle

decreased cardiac muscle contractility ( J:154303 )

• mice exhibit decreased fractional shortening compared with wild-type mice

Genotype
MGI:4367884

ht2

• Allelic Composition: Aplnr^tm1.1Tq/Aplnr⁺
• Genetic Background: C57BL/6-Aplnr^tm1.1Tq

reproductive system

decreased litter size ( J:154303 )

• mice produce smaller than expected litter sizes due at least in part to poor maternal care

• however, survival of young is improved by fostering with outbred CD-1 strain mothers

behavior/neurological

abnormal maternal behavior ( J:154303 )

♀ • mice produce smaller than expected litter sizes due at least in part to poor maternal care