Analysis Tools|
Allele Symbol Allele Name Allele ID |
Wdr83tm1Guwo targeted mutation 1, Gunter Wolf MGI:4367006 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice die at E10.5
|
|
• vascularization by E10.5 is diffuse unlike in wild-type mice
|
|
• mice exhibit placental insufficiency
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice subjected to kidney ischemia and reperfusion exhibit reduced tubular apoptosis compared with similarly treated wild-type mice
|
|
• mice subjected to kidney ischemia and reperfusion exhibit reduced tubular damage, inflammation, and apoptosis with improved renal function, as measured by serum creatinine and urea, compared with similarly treated wild-type mice
|
|
• following kidney ischemia and reperfusion, mice exhibit kidney inflammation that is not as severe as in similarly treated wild-type mice
|
|
• following kidney ischemia and reperfusion, mice exhibit lower serum creatinine levels compared to in similarly treated wild-type mice
|
|
• following kidney ischemia and reperfusion, mice exhibit lower serum urea levels compared to similarly treated wild-type mice
|
|
• mice subjected to kidney ischemia and reperfusion exhibit reduced tubular damage, inflammation, and apoptosis with improved renal function, as measured by serum creatinine and urea, compared with similarly treated wild-type mice
|
|
• following kidney ischemia and reperfusion, mice exhibit kidney inflammation that is not as severe as in similarly treated wild-type mice
|
|
• mice subjected to kidney ischemia and reperfusion exhibit reduced tubular apoptosis compared with similarly treated wild-type mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
