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Allele Symbol Allele Name Allele ID |
Wdr83tm1Guwo targeted mutation 1, Gunter Wolf MGI:4367006 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die at E10.5
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• vascularization by E10.5 is diffuse unlike in wild-type mice
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• mice exhibit placental insufficiency
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice subjected to kidney ischemia and reperfusion exhibit reduced tubular apoptosis compared with similarly treated wild-type mice
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• mice subjected to kidney ischemia and reperfusion exhibit reduced tubular damage, inflammation, and apoptosis with improved renal function, as measured by serum creatinine and urea, compared with similarly treated wild-type mice
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• following kidney ischemia and reperfusion, mice exhibit kidney inflammation that is not as severe as in similarly treated wild-type mice
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• following kidney ischemia and reperfusion, mice exhibit lower serum creatinine levels compared to in similarly treated wild-type mice
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• following kidney ischemia and reperfusion, mice exhibit lower serum urea levels compared to similarly treated wild-type mice
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• mice subjected to kidney ischemia and reperfusion exhibit reduced tubular damage, inflammation, and apoptosis with improved renal function, as measured by serum creatinine and urea, compared with similarly treated wild-type mice
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• following kidney ischemia and reperfusion, mice exhibit kidney inflammation that is not as severe as in similarly treated wild-type mice
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• mice subjected to kidney ischemia and reperfusion exhibit reduced tubular apoptosis compared with similarly treated wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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