Phenotypes associated with this allele

• Allele Symbol: Dse^tm1Mmac
• Allele Name: targeted mutation 1, Marco Maccarana
• Allele ID: MGI:4366965
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dse^tm1Mmac/Dse^tm1Mmac	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4366985

Genotype
MGI:4366985

hm1

• Allelic Composition: Dse^tm1Mmac/Dse^tm1Mmac
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased litter size ( J:153897 )

growth/size/body

decreased birth body size ( J:153897 )

• 20% to 30%

decreased body weight ( J:153897 )

• 10% at 80 days

decreased body length ( J:153897 )

• 5% to 10% at 80 days

limbs/digits/tail

kinked tail ( J:153897 )

• mice exhibit a tail kink at birth that resolves by 4 weeks of age

integument

abnormal hypodermis morphology ( J:153897 )

• the hypodermal layer contains sparser loose connective tissue compared to in wild-type mice

abnormal cutaneous collagen fibril morphology ( J:153897 )

• skin collagen fibrils are thicker than in wild-type mice

decreased skin tensile strength ( J:153897 )