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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trpm6tm1.1Rws
targeted mutation 1.1, Richard W Stokes
MGI:4366769
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trpm6tm1.1Rws/Trpm6tm1.1Rws involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N MGI:4366771
ht2
Trpm6tm1.1Rws/Trpm6+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N MGI:4366772


Genotype
MGI:4366771
hm1
Allelic
Composition
Trpm6tm1.1Rws/Trpm6tm1.1Rws
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm6tm1.1Rws mutation (0 available); any Trpm6 mutation (111 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• one of the four mice fed a high magnesium diet since gestation that survived weaning died within a week of weaning
• fewer than expected mice are detected at E16.5 to E18.5
• mice almost never survive to weaning
• when fed a high magnesium diet from gestation, survival at weaning is improved but fewer than expected mice are present
• fewer than expected mice are detected at E12.5

reproductive system
• homozygous mice fed a high magnesium diet from gestation fail to produce offspring when mated to each other but produce offspring when mated with heterozygous mice

nervous system
• mice that survive to late gestation or P1 exhibit a small hole in the head or neck
• in many mice
• due to a defect in closure of the calvarium in one mouse

craniofacial

embryo
• mice that survive to late gestation or P1 exhibit a small hole in the head or neck
• in many mice

growth/size/body
• E16.5, E17.5, and E18.5
• E16.5, E17.5, and E18.5

skeleton
• in many mice




Genotype
MGI:4366772
ht2
Allelic
Composition
Trpm6tm1.1Rws/Trpm6+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm6tm1.1Rws mutation (0 available); any Trpm6 mutation (111 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• day 60 mortality is 4.7% compared to 0% in wild-type mice whether fed a high magnesium diet or not

homeostasis/metabolism
• mice exhibit modestly lower magnesium serum levels than in wild-type mice
• however, renal and fecal excretion of magnesium is normal





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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory