Phenotypes associated with this allele

• Allele Symbol: Aqp3^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:4366758
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aqp3^m1Btlr/Aqp3^m1Btlr	C57BL/6J-Aqp3^m1Btlr	MGI:4366759

Genotype
MGI:4366759

hm1

• Allelic Composition: Aqp3^m1Btlr/Aqp3^m1Btlr
• Genetic Background: C57BL/6J-Aqp3^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:153279 )

• increased susceptibility to dextran sulfate sodium (DSS) induced colitis

• death approximately 5 days after initiation of DSS treatment

cardiovascular system

intestinal hemorrhage ( J:153279 )

• increased intestinal bleeding relative to wild-type mice from day 3 on 1% DSS treatment

digestive/alimentary system

intestinal hemorrhage ( J:153279 )

• increased intestinal bleeding relative to wild-type mice from day 3 on 1% DSS treatment

increased susceptibility to induced colitis ( J:153279 )

• increased susceptibility to dextran sulfate sodium (DSS) induced colitis

• increased weight loss relative to wild-type mice from day 3 on 1% DSS treatment

• increased intestinal bleeding relative to wild-type mice from day 3 on 1% DSS treatment

• histological analysis reveals development of lymphoid tissue within the wall of the mutant colon by day 3 of DSS treatment, while the colons of DSS treated wild-type mice appear indistinguishable from those of untreated mice

• death approximately 5 days after initiation of DSS treatment

growth/size/body

increased susceptibility to weight loss ( J:153279 )

• increased weight loss relative to wild-type mice from day 3 on 1% DSS treatment

immune system

increased susceptibility to induced colitis ( J:153279 )

• increased susceptibility to dextran sulfate sodium (DSS) induced colitis

• increased weight loss relative to wild-type mice from day 3 on 1% DSS treatment

• increased intestinal bleeding relative to wild-type mice from day 3 on 1% DSS treatment

• histological analysis reveals development of lymphoid tissue within the wall of the mutant colon by day 3 of DSS treatment, while the colons of DSS treated wild-type mice appear indistinguishable from those of untreated mice

• death approximately 5 days after initiation of DSS treatment

abnormal gut-associated lymphoid tissue morphology ( J:153279 )

• histological analysis reveals development of lymphoid tissue within the wall of the mutant colon by day 3 of DSS treatment, while the colons of DSS treated wild-type mice appear indistinguishable from those of untreated mice