Analysis Tools
nervous system
|
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice
|
|
• mice exhibit age-dependent somatodendritic aggregations of phosphorylated tau protein unlike in wild-type mice
|
|
• age-dependent neuron loss is observed in mice older than 18 months in the CA3 region and to a lesser extent in the dentate gyrus unlike in wild-type mice
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice
|
behavior/neurological
| N |
• mice exhibit normal excitability and exploratory behavior
|
|
• at 8 months, mice exhibit a decrease in spontaneous alteration in a Y-maze unlike wild-type mice
• however, young mice and mice treated with lithium exhibit normal working memory
|
homeostasis/metabolism
|
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice
|
cellular
|
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:153738 | ||
