Phenotypes associated with this allele

• Allele Symbol: Nppc^tm1.1Fgr
• Allele Name: targeted mutation 1.1, Fritz G Rathjen
• Allele ID: MGI:4365461
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nppc^tm1.1Fgr/Nppc^tm1.1Fgr	involves: 129P2/OlaHsd * C57BL/6J	MGI:4365534
cx2	Nppc^tm1.1Fgr/Nppc^tm1.1Fgr Tg(Thy1-YFP)HJrs/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA	MGI:4365536

Genotype
MGI:4365534

hm1

• Allelic Composition: Nppc^tm1.1Fgr/Nppc^tm1.1Fgr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal sensory neuron innervation pattern ( J:153212 )

• sensory axons lack T- or Y-shaped branches at all trunk levels in the dorsal root entry zone unlike in wild-type mice

• unlike in wild-type mice, axons entering the spinal cord and turn either in rostral or caudal directions without leaving the funiculus

• however, collateral formation is normal

abnormal neuron physiology ( J:153212 )

• fewer dorsal horn neurons respond to capsaicin compared to in similarly treated wild-type mice

abnormal miniature excitatory postsynaptic currents ( J:153212 )

• miniature excitatory postsynaptic current are reduced in capsaicin-treated mice compared to in similarly treated wild-type mice

growth/size/body

decreased body height ( J:153212 )

• short stature

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:153212 )

• capsaicin-treated mice exhibit fewer dorsal horn neurons responding and reduced miniature excitatory postsynaptic current compared with similarly treated wild-type mice

Genotype
MGI:4365536

cx2

• Allelic Composition: Nppc^tm1.1Fgr/Nppc^tm1.1Fgr; Tg(Thy1-YFP)HJrs/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

nervous system

abnormal sensory neuron innervation pattern ( J:153212 )

• at mature stages all sensory axon exhibit a bifurcation failure compared to in wild-type mice