Phenotypes associated with this allele

• Allele Symbol: Ctsa^tm1.1Avps
• Allele Name: targeted mutation 1.1, Alexey Pshezhetsky
• Allele ID: MGI:4365386
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctsa^tm1.1Avps/Ctsa^tm1.1Avps	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:4365391

Genotype
MGI:4365391

hm1

• Allelic Composition: Ctsa^tm1.1Avps/Ctsa^tm1.1Avps
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:153297 )

N • mice exhibit a normal lifespan

reproductive system

reproductive system phenotype ( J:153297 )

N • mice are fertile

cardiovascular system

abnormal blood vessel elastic tissue morphology ( J:153297 )

• arterial elastic fibers in the tunica adventitia are decreased compared to in wild-type mice

increased mean systemic arterial blood pressure ( J:153297 )

increased systemic arterial diastolic blood pressure ( J:153297 )

• at night and during the day when mice are fed a standard or high salt diet

increased systemic arterial systolic blood pressure ( J:153297 )

• at night and during the day when mice are fed a standard or high salt diet

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:153297 )

• mice fed a high salt diet and treated with endothelin-1 fail to exhibit an increase in blood pressure as in similarly treated wild-type mice

• degradation of endothelin-1 in lung cells is decreased compared to in wild-type mice

respiratory system

overexpanded pulmonary alveolus ( J:153297 )

abnormal pulmonary elastic fiber morphology ( J:153297 )

• the alveolar septae of the lung exhibits decreased elastic fibers compared to in wild-type mice

behavior/neurological

increased fluid intake ( J:153297 )

• when fed a high salt diet

renal/urinary system

polyuria ( J:153297 )

• when fed a high salt diet

growth/size/body

growth/size/body region phenotype ( J:153297 )

N • mice exhibit normal growth

integument

abnormal cutaneous elastic fiber morphology ( J:153297 )

• dermal elastic fibers are reduced compared to in wild-type mice

• cultured skin fibroblasts exhibit impaired deposition of insoluble elastin compared with wild-type cells