All Phenotypes Igsf11<tm1a(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igsf11^{tm1a(KOMP)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4364956

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igsf11^{tm1a(KOMP)Wtsi}/Igsf11^{tm1a(KOMP)Wtsi}	involves: C57BL/6N	MGI:5897631

Allelic Composition	Igsf11^{tm1a(KOMP)Wtsi}/Igsf11^{tm1a(KOMP)Wtsi}
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0297_2_A07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igsf11^{tm1a(KOMP)Wtsi} mutation (1 available); any Igsf11 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:234439 )

N	• mice exhibit normal levels of immature AMPARs

decreased excitatory postsynaptic current amplitude ( J:234439 )

• decreased miniature EPSCs in dentate gyrus granule cells

• however, frequency is normal and mEPSC amplitude and frequency in hippocampal CA1 pyramidal neurons is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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