All Phenotypes Gys2<tm1a(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gys2^{tm1a(KOMP)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4364592

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi}	B6J.B6N-Gys2^{tm1a(KOMP)Wtsi}	MGI:5568697
hm2	Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi}	B6JTyr;B6N-Gys2^{tm1a(KOMP)Wtsi}/Wtsi	MGI:5781635
ht3	Gys2^{tm1a(KOMP)Wtsi}/Gys2⁺	B6J.B6N-Gys2^{tm1a(KOMP)Wtsi}	MGI:5568695

Allelic Composition	Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi}
Genetic Background	B6J.B6N-Gys2^{tm1a(KOMP)Wtsi}
Cell Lines	EPD0086_2_F11

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gys2^{tm1a(KOMP)Wtsi} mutation (2 available); any Gys2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased liver glycogen level ( J:208923 )

• hepatocytes contain only a trace of glycogen

liver/biliary system

decreased liver glycogen level ( J:208923 )

• hepatocytes contain only a trace of glycogen

Allelic Composition	Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi}
Genetic Background	B6JTyr;B6N-Gys2^{tm1a(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0086_2_F11

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gys2^{tm1a(KOMP)Wtsi} mutation (2 available); any Gys2 mutation (45 available)

Data Sources

IMPC Data for Gys2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

decreased circulating glycerol level ( J:175295 )

IMPC - WTSI

increased circulating calcium level ( J:165965 )

IMPC - WTSI

increased circulating sodium level ( J:165965 )

IMPC - WTSI

increased circulating total protein level ( J:165965 )

IMPC - WTSI

increased circulating chloride level ( J:165965 )

IMPC - WTSI

integument

abnormal vibrissa morphology ( J:175295 )

IMPC - WTSI

growth/size/body

decreased body weight ( J:165965 )

IMPC - WTSI

Allelic Composition	Gys2^{tm1a(KOMP)Wtsi}/Gys2⁺
Genetic Background	B6J.B6N-Gys2^{tm1a(KOMP)Wtsi}
Cell Lines	EPD0086_2_F11

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gys2^{tm1a(KOMP)Wtsi} mutation (2 available); any Gys2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:208923 )

N	• mice exhibit normal blood glucose and liver glycogen levels after glucose injection

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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