Phenotypes associated with this allele

• Allele Symbol: Ecscr^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4364516
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ecscr^tm1a(KOMP)Wtsi/Ecscr^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:5816494

Genotype
MGI:5816494

hm1

• Allelic Composition: Ecscr^{tm1a(KOMP)Wtsi}/Ecscr^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:236657 )

N • fasting mice show no differences in total plasma cholesterol or HDL-associated plasma cholesterol levels relative to wild-type controls

increased circulating free fatty acids level ( J:236657 )

• fasting mice show significantly elevated serum free fatty acid (FFA) levels

• excess FFAs are associated with both high density and low-density lipoprotein fractions

increased circulating glycerol level ( J:236657 )

• fasting mice show significantly increased free glycerol levels

increased circulating triglyceride level ( J:236657 )

• fasting mice show significantly elevated serum esterified triglyceride (TG) levels

• excess TGs are associated with both high density and low-density lipoprotein fractions

enhanced lipolysis ( J:236657 )

• fasting mice exhibit a modest increase in basal lipolysis relative to wild-type controls

• both basal and insulin-dependent suppression of lipolysis is impaired

adipose tissue

abnormal white adipose tissue physiology ( J:236657 )

• ex vivo, differentiated adipocyte cells show reduced insulin-dependent AKT phosphorylation and a trend toward increased hormone sensitive lipase (HSL) phosphorylation

• epididymal white adipose tissue (WAT) isolated from adult male mice shows depressed AKT activation, enhanced HSL phosphorylation, and increased PTEN protein levels relative to wild-type WAT

• however, epididymal WAT appears grossly normal, although the modal adipocyte area size is somewhat decreased

growth/size/body

growth/size/body region phenotype ( J:236657 )

N • mice fed a high-fat diet at weaning show no differences in initial weight gain relative to HFD-fed wild-type controls

cardiovascular system

cardiovascular system phenotype ( J:236657 )

N • mice exhibit no major angiogenesis defects