Phenotypes associated with this allele

• Allele Symbol: Gm5544^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4364386
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gm5544^tm1a(KOMP)Wtsi/Gm5544^tm1a(KOMP)Wtsi	C57BL/6N-Gm5544^tm1a(KOMP)Wtsi/Wtsi	MGI:5700904
ht2	Gm5544^tm1a(KOMP)Wtsi/Gm5544^+	C57BL/6N-Gm5544^tm1a(KOMP)Wtsi/Wtsi	MGI:5706015

Genotype
MGI:5700904

hm1

• Allelic Composition: Gm5544^{tm1a(KOMP)Wtsi}/Gm5544^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Gm5544^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0164_6_A12

Data Sources

IMPC Data for Gm5544

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal umbilical vein topology ( J:239583 )

DMDD

abnormal pericardial cavity morphology ( J:239583 )

DMDD

craniofacial

abnormal basisphenoid bone morphology ( J:239583 )

DMDD

basisphenoid bone foramen ( J:239583 )

DMDD

occipital bone foramen ( J:239583 )

DMDD

embryo

abnormal umbilical vein topology ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

immune system

blood in lymph vessels ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

limbs/digits/tail

polydactyly ( J:239583 )

DMDD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI

muscle

abnormal eye muscle morphology ( J:239583 )

DMDD

neoplasm

embryo tumor ( J:239583 )

DMDD

nervous system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

exencephaly ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

abnormal intrathoracic topology of vagus nerve ( J:239583 )

DMDD

renal/urinary system

small kidney ( J:239583 )

DMDD

skeleton

abnormal basisphenoid bone morphology ( J:239583 )

DMDD

basisphenoid bone foramen ( J:239583 )

DMDD

occipital bone foramen ( J:239583 )

DMDD

fusion of vertebral arches ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

Genotype
MGI:5706015

ht2

• Allelic Composition: Gm5544^{tm1a(KOMP)Wtsi}/Gm5544⁺
• Genetic Background: C57BL/6N-Gm5544^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0164_6_A12

Data Sources

IMPC Data for Gm5544

hematopoietic system

decreased marginal zone B cell number ( J:211773 )

IMPC - WTSI

immune system

decreased marginal zone B cell number ( J:211773 )

IMPC - WTSI