Phenotypes associated with this allele

• Allele Symbol: Rc3h2^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4364357
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rc3h2^tm1a(KOMP)Wtsi/Rc3h2^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:5510236
hm2	Rc3h2^tm1a(KOMP)Wtsi/Rc3h2^tm1a(KOMP)Wtsi	involves: C57BL/6N * NMRI	MGI:5510237

Genotype
MGI:5510236

hm1

• Allelic Composition: Rc3h2^{tm1a(KOMP)Wtsi}/Rc3h2^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:196136 )

• born within Mendelian ratios but many die within the first few days after birth

• decreasing vitality from birth to weaning

• Background Sensitivity: surviving males and females are healthy and fertile

growth/size/body

decreased body size ( J:196136 )

decreased body weight ( J:196136 )

• Background Sensitivity: decreased body mass of both males and females as compared to controls

limbs/digits/tail

limbs/digits/tail phenotype ( J:196136 )

N • no tail malformation

respiratory system

abnormal lung development ( J:196136 )

• somewhat immature lung phenotype

abnormal lung alveolus development ( J:196136 )

• decreased expansion of alveoli

• delayed clearance of amniotic fluid from the alveolar space

nervous system

nervous system phenotype ( J:196136 )

N • neural tube closure is normal

Genotype
MGI:5510237

hm2

• Allelic Composition: Rc3h2^{tm1a(KOMP)Wtsi}/Rc3h2^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N * NMRI
• Cell Lines: EPD0131_2_B09

mortality/aging

postnatal lethality, incomplete penetrance ( J:196136 )

• born within Mendelian ratios but many die within the first few days after birth

• decreasing vitality from birth to weaning

• Background Sensitivity: mixed background improves survival of both males and females

growth/size/body

decreased body size ( J:196136 )

decreased body weight ( J:196136 )

• Background Sensitivity: decreased body size and mass only in males

limbs/digits/tail

limbs/digits/tail phenotype ( J:196136 )

N • no tail malformation

respiratory system

abnormal lung development ( J:196136 )

• somewhat immature lung phenotype

abnormal lung alveolus development ( J:196136 )

• decreased expansion of alveoli

• delayed clearance of amniotic fluid from the alveolar space

nervous system

nervous system phenotype ( J:196136 )

N • neural tube closure is normal

immune system

immune system phenotype ( J:196136 )

N • immune cell homeostasis is normal