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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Aldh18a1tm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4363671
Summary 2 genotypes


Genotype
MGI:6261833
hm1
Allelic
Composition
Aldh18a1tm1a(KOMP)Wtsi/Aldh18a1tm1a(KOMP)Wtsi
Genetic
Background
C57BL/6N-Aldh18a1tm1a(KOMP)Wtsi/Wtsi
Cell Lines EPD0071_1_D03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh18a1tm1a(KOMP)Wtsi mutation (2 available); any Aldh18a1 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes are not viable at P14




Genotype
MGI:6272787
ht2
Allelic
Composition
Aldh18a1tm1a(KOMP)Wtsi/Aldh18a1+
Genetic
Background
C57BL/6N-Aldh18a1tm1a(KOMP)Wtsi/Wtsi
Cell Lines EPD0071_1_D03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh18a1tm1a(KOMP)Wtsi mutation (2 available); any Aldh18a1 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• at necropsy (16.1 weeks of age), mice fed a high-fat diet show mild, multifocal mixed inflammatory cell infiltration with mild fibrosis and distortion of adipocytes in the hypodermal fat layer
• mild, multifocal mixed inflammatory cell infiltration in the hypodermal fat layer
• mild fibrosis in the hypodermal fat layer

adipose tissue
• at necropsy (16.1 weeks of age), mice fed a high-fat diet show mild, multifocal mixed inflammatory cell infiltration with mild fibrosis and distortion of adipocytes in the hypodermal fat layer

immune system
• mild, multifocal mixed inflammatory cell infiltration in the hypodermal fat layer





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory