Phenotypes associated with this allele

• Allele Symbol: Krt76^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363117
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Krt76^tm1a(KOMP)Wtsi/Krt76^tm1a(KOMP)Wtsi	C57BL/6-Krt76^tm1a(KOMP)Wtsi	MGI:5641690
hm2	Krt76^tm1a(KOMP)Wtsi/Krt76^tm1a(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:6273143
ht3	Krt76^tm1a(KOMP)Wtsi/Krt76^+	B6Brd;B6N-Tyr^c-Brd Krt76^tm1a(KOMP)Wtsi/Wtsi	MGI:6273142
ht4	Krt76^tm1a(KOMP)Wtsi/Krt76^+	C57BL/6-Krt76^tm1a(KOMP)Wtsi	MGI:5641691

Genotype
MGI:5641690

hm1

• Allelic Composition: Krt76^{tm1a(KOMP)Wtsi}/Krt76^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6-Krt76^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0106_2_B05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal sebaceous gland morphology ( J:209956 )

• tail shows abnormal sebaceous gland morphology

enlarged sebaceous gland ( J:209956 )

abnormal hair cycle ( J:209956 )

abnormal epidermal layer morphology ( J:209956 )

• scales on the tail are not clearly defined and instead the granular layer is continuous

• tail interfollicular epidermis contains ectopic sebocytes

• interfollicular epidermis hyperproliferation

abnormal epidermis stratum basale morphology ( J:209956 )

• tail shows abnormal stratum basale, with basal layer hyperproliferation

thick epidermis ( J:209956 )

• tail skin shows epidermal thickening

flaky skin ( J:209956 )

• flaky tail skin

increased foot pad pigmentation ( J:209956 )

• footpads are darkly pigmented

increased tail pigmentation ( J:209956 )

• tail is darkly pigmented

endocrine/exocrine glands

abnormal sebaceous gland morphology ( J:209956 )

• tail shows abnormal sebaceous gland morphology

enlarged sebaceous gland ( J:209956 )

limbs/digits/tail

increased foot pad pigmentation ( J:209956 )

• footpads are darkly pigmented

abnormal tail morphology ( J:209956 )

• scales on the tail are not clearly defined and instead the granular layer is continuous

increased tail pigmentation ( J:209956 )

• tail is darkly pigmented

pigmentation

increased foot pad pigmentation ( J:209956 )

• footpads are darkly pigmented

increased tail pigmentation ( J:209956 )

• tail is darkly pigmented

Genotype
MGI:6273143

hm2

• Allelic Composition: Krt76^{tm1a(KOMP)Wtsi}/Krt76^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0106_2_B05

integument

skin inflammation ( J:232539 )

hyperkeratosis ( J:232539 )

parakeratosis ( J:232539 )

pigment incontinence ( J:232539 )

pigmentation

pigment incontinence ( J:232539 )

immune system

skin inflammation ( J:232539 )

Genotype
MGI:6273142

ht3

• Allelic Composition: Krt76^{tm1a(KOMP)Wtsi}/Krt76⁺
• Genetic Background: B6Brd;B6N-Tyr^c-Brd Krt76^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0106_2_B05

integument

abnormal coat appearance ( J:232539 )

sparse hair ( J:232539 )

rough coat ( J:232539 )

Genotype
MGI:5641691

ht4

• Allelic Composition: Krt76^{tm1a(KOMP)Wtsi}/Krt76⁺
• Genetic Background: C57BL/6-Krt76^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0106_2_B05

integument

abnormal coat appearance ( J:209956 )

• small percentage of mice show abnormal dorsal hair coat

• however, mice do not have any obvious skin abnormalities