Phenotypes associated with this allele

• Allele Symbol: Padi3^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362791
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Padi3^tm1a(KOMP)Wtsi/Padi3^tm1a(KOMP)Wtsi	involves: C57BL/6N * C57BL/6NCrl	MGI:5816273

Genotype
MGI:5816273

hm1

• Allelic Composition: Padi3^{tm1a(KOMP)Wtsi}/Padi3^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N * C57BL/6NCrl
• Cell Lines: EPD0317_4_E05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal coat/ hair morphology ( J:237330 )

• at 7 weeks of age, scanning electron microscopy (SEM) revealed structural alterations in hair coat morphology

• however, the skin appears grossly normal

coarse hair ( J:237330 )

• at 7 weeks of age, the surface of the proximal part of the vibrissae and the hairs on the entire length are irregular and rough and appear as if hammered

• in some cases, hairs are twisted

rough coat ( J:237330 )

• at 7 weeks of age, SEM analysis of back hair coat revealed that most hairs are rough with an irregular surface; this is noted in both thick and thin hairs

abnormal hair shaft morphology ( J:237330 )

abnormal vibrissa morphology ( J:237330 )

• at 7 weeks of age, whisker morphology is altered to a lesser extent than hair coat morphology