Phenotypes associated with this allele

• Allele Symbol: Acod1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362443
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acod1^tm1a(KOMP)Wtsi/Acod1^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:5805933

Genotype
MGI:5805933

hm1

• Allelic Composition: Acod1^{tm1a(KOMP)Wtsi}/Acod1^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:235002 )

• in response to LPS stimulation, mutant bone marrow-derived macrophages (BMDMs) fail to produce itaconate (a metaboilte that modulates succinate levels via succinate dehydrogenase inhibition) and exhibit significantly decreased succinate accumulation relative to LPS-induced wild-type BMDMs

hematopoietic system

abnormal macrophage physiology ( J:235002 )

• in response to LPS stimulation, mutant bone marrow-derived macrophages (BMDMs) fail to produce itaconate (a metaboilte that modulates succinate levels via succinate dehydrogenase inhibition) and exhibit significantly decreased succinate accumulation relative to LPS-induced wild-type BMDMs